DNA hypermethylation induced by Epstein-Barr virus in the development of Epstein-Barr virus-associated gastric carcinoma

다국어 초록 (Multilingual Abstract)

Epstein-Barr virus (EBV)-associated gastriccarcinoma (EBVaGC) is a recently recognized diseaseentity defined by the presence of EBV in gastric carcinomacells. EBV infection causes major epigenetic alterations inthe EBV genome and its cellular host genome, suggestingthat EBV acts as a direct epigenetic driver for EBVaGC.
One of the major epigenetic events in the viral and cellulargenomes to control transcription is DNA hypo- or hypermethylation.
Particularly, local and global hypermethylationhave been reported in EBVaGC. It is thereforeimportant to understand the molecular mechanisms ofDNA hypermethylation during EBVaGC carcinogenesis.
To understand the functional roles of DNA methylationand suggest therapeutic target candidates for EBVaGC, wereviewed recent literature reporting DNA hypermethylationin EBVaGC. We summarized the identified candidategenes that are markedly hypermethylated in EBVaGC,which can potentially be targets for chemotherapies withdemethylating agents.

참고문헌 (Reference)

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