증례 : 알레르기 ; 종합비타민 정주투여 후 발생한 과민반응 4예 = Allergy ; Allergic reactions to a multivitamin

국문 초록 (Abstract)

종합비타민 주사제에 의한 아나필락시스 반응 4예를 경험하였고, 피부반응 검사로 과민반응을 확인하였다. 또한 종합비타민제에 대한 유해반응이 드물지 않게 발생하므로 적절한 적응증 없이 불필요하게 비타민제재를 투여하는 것은 피하도록 하여야겠다.

다국어 초록 (Multilingual Abstract)

Parenteral vitamin supplements are frequently used in normal subjects and patients with vitamin deficiencies. The incidence rate of an allergic reaction to a multivitamin is less than 0.1%. We recently experienced four young patients who showed severe immediate allergic reactions after administration of an intravenous multivitamin. A 21-year-old male who was admitted for diarrhea suddenly felt chest tightness, shortness of breath, high fever, and generalized pruritus with facial flushing within a few minutes after beginning a dextrose fluid drip mixed with a multivitamin solution. The patient`s symptoms subsided in 20 minutes after fluid administration stopped. The patient showed positive response to intradermal tests using a multivitamin, vitamin B-complex, and thiamine solution. We also observed similar responses to a multivitamin in three other young patients, and all of them showed positive reactions on a skin test using a multivitamin solution. Including the above-described patients, we have experienced 17 cases of potential multivitamin-induced hypersensitivity reactions over the past year. Based on our experience, multivitamin-related allergic reactions are not rare. Therefore, more attention to vitamins as a cause of severe allergic adverse reaction is required. (Korean J Med 77:S1347-S1351, 2009)