급성위점막병변에 대한 실험적 연구 = Experimental Study on Acute Gastric Mucosal Lesion

다국어 초록 (Multilingual Abstract)

Acute gastric mucosal lesions (AGM lesions) is a general term applied to conditions characterized by the acute development of mucosal lesions in the form of erythema, mucosal hemorrhage, erosions and ulcerations in the mucosa of the stomach and duodenum.
Although the pathophysiological events leadings to the formation of these lesions remain unknown, we do know that they are after preceded by one of many situations. It has become traditional to use the term stress ulcer to describe AGM lesions preceded by a major stress such as that of an operation or of severe thermal burns or hemorrhagic shock. The salient clinical manifestation of acute gastric mucosal lesions, regardless of their cause, is bleeding. AGM lesions were experimentally produced by brain injury and administration of steroid.
This experimental study was conducted in order to study the socalled AGM lesions, espicially on production and pathology of them.
The experimental animals, normal adult rate, were divided into 4 groups the first group of brain injury, the second group of brain injury and administration of steroid, the third group of administration of steroid only, and the fourth group of normal control with administration of normal saline and normal rats.
The frequency of AGM lesions was studied in relation to each experimental group, experimental period and grade of leions. The AGM lesions were divided into 3 grades depending on the macroscopic and microscopic findings.
1. AGM lesions were observed in 34 out of 63 all experimental animals except for control group of animal.
Majority of the lesions were found in the grandular portion of the stomach.
2. In the brain injured group, the lesions that was erythematous and superficial mucosal erosion were found in 3 out of 21 (14.3%), which were observed only in experimental period of 3-5 days.
3. In the group with brain injury and steroid administration, the lesions were found in 15 out of 21 animals (76.2%) among them grade 1 was in 2 out of 16, grade 2 in 10 and grade 3 in 4, which were observed in the period of 2-7 days.
4. In the group with administration of steroid, the lesions were found in 15 out of 21 animals (71.4%), among them grade 1 was 2 out of 15, grade 2 in 11 and grade 3 in 2, which started to be observed form 2nd day through out the experimental period.
5. No lesions were investigated in the control group. No correlation between the variety of brain injury and production of AGM lesion was studied.