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      KCI등재 SCOPUS SCIE

      Resveratrol Alters microRNA Expression Profiles in A549 Human Non-Small Cell Lung Cancer Cells

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      https://www.riss.kr/link?id=A104828963

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      다국어 초록 (Multilingual Abstract)

      Resveratrol is a plant phenolic phytoalexin that has been reported to have antitumor properties in several types of cancers. In particular, several studies have suggested that resveratrol exerts antiproliferative effects against A549 human non-small cell lung cancer cells; however, its me-chanism of action remains incompletely understood. Deregulation of microRNAs (miRNAs), a class of small, non-coding, regulatory RNA molecules involved in gene expression, is strongly correlated with lung cancer. In this study, we demonstrated that resveratrol treatment altered miRNA expression in A549 cells. Using microarray analysis, we identified 71 miRNAs exhibiting greater than 2-fold expression changes in resveratrol-treated cells relative to their expression levels in untreated cells. Furthermore, we identified target genes related to apoptosis, cell cycle regulation, cell proliferation, and differentiation using a miRNA target-prediction program. In conclusion, our data demonstrate that resveratrol induces considerable changes in the miRNA expression profiles of A549 cells, suggesting a novel approach for studying the anticancer mechanisms of resveratrol.
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      Resveratrol is a plant phenolic phytoalexin that has been reported to have antitumor properties in several types of cancers. In particular, several studies have suggested that resveratrol exerts antiproliferative effects against A549 human non-small c...

      Resveratrol is a plant phenolic phytoalexin that has been reported to have antitumor properties in several types of cancers. In particular, several studies have suggested that resveratrol exerts antiproliferative effects against A549 human non-small cell lung cancer cells; however, its me-chanism of action remains incompletely understood. Deregulation of microRNAs (miRNAs), a class of small, non-coding, regulatory RNA molecules involved in gene expression, is strongly correlated with lung cancer. In this study, we demonstrated that resveratrol treatment altered miRNA expression in A549 cells. Using microarray analysis, we identified 71 miRNAs exhibiting greater than 2-fold expression changes in resveratrol-treated cells relative to their expression levels in untreated cells. Furthermore, we identified target genes related to apoptosis, cell cycle regulation, cell proliferation, and differentiation using a miRNA target-prediction program. In conclusion, our data demonstrate that resveratrol induces considerable changes in the miRNA expression profiles of A549 cells, suggesting a novel approach for studying the anticancer mechanisms of resveratrol.

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      참고문헌 (Reference)

      1 Wha Ja Cho, "miR-372 Regulates Cell Cycle and Apoptosis of AGS Human Gastric Cancer Cell Line through Direct Regulation of LATS2" 한국분자세포생물학회 28 (28): 521-527, 2009

      2 Stervbo, U., "Time-and concentration-dependent effects of resveratrol in HL-60 and HepG2 cells" 39 : 479-493, 2006

      3 Chen, J.F., "The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation" 38 : 228-233, 2006

      4 Ambros, V., "The regulation of genes and genomes by small RNAs" 134 : 1635-1641, 2007

      5 Guo L., "The fate of miRNA* strand through Evolutionary anlysis: Implication for degradation as carrier strand or potential regulatory molecules" 5 : 11387-, 2010

      6 Aggarwal, B.B., "Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies" 24 : 2783-2840, 2004

      7 Delmas, D., "Resveratrol: preventing properties against vascular alterations and ageing" 49 : 377-395, 2005

      8 Soleas, G.J., "Resveratrol: a molecule whose time has come? And gone" 30 : 91-113, 1997

      9 Stewart, J.R., "Resveratrol: a candidate nutritional substance for prostate cancer prevention" 133 : 2440-2443, 2003

      10 Moammir, H.A., "Resveratrol-caused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of phosphatidylinositol 3′-kinase/Akt pathway and Bcl-2 family proteins" 5 : 1335-1341, 2006

      1 Wha Ja Cho, "miR-372 Regulates Cell Cycle and Apoptosis of AGS Human Gastric Cancer Cell Line through Direct Regulation of LATS2" 한국분자세포생물학회 28 (28): 521-527, 2009

      2 Stervbo, U., "Time-and concentration-dependent effects of resveratrol in HL-60 and HepG2 cells" 39 : 479-493, 2006

      3 Chen, J.F., "The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation" 38 : 228-233, 2006

      4 Ambros, V., "The regulation of genes and genomes by small RNAs" 134 : 1635-1641, 2007

      5 Guo L., "The fate of miRNA* strand through Evolutionary anlysis: Implication for degradation as carrier strand or potential regulatory molecules" 5 : 11387-, 2010

      6 Aggarwal, B.B., "Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies" 24 : 2783-2840, 2004

      7 Delmas, D., "Resveratrol: preventing properties against vascular alterations and ageing" 49 : 377-395, 2005

      8 Soleas, G.J., "Resveratrol: a molecule whose time has come? And gone" 30 : 91-113, 1997

      9 Stewart, J.R., "Resveratrol: a candidate nutritional substance for prostate cancer prevention" 133 : 2440-2443, 2003

      10 Moammir, H.A., "Resveratrol-caused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of phosphatidylinositol 3′-kinase/Akt pathway and Bcl-2 family proteins" 5 : 1335-1341, 2006

      11 Kasdallah-Grissa, A., "Resveratrol, a red wine polyphenol, attenuates ethanol-induced oxidative stress in rat liver" 80 : 1033-1039, 2007

      12 Matsuoka, A., "Resveratrol, a naturally occurring polyphenol, induces sister chromatid exchanges in a Chinese hamster lung (CHL) cell line" 494 : 107-113, 2001

      13 Revel, A., "Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects lung from DNA damage and apoptosis caused by benzo[a]pyrene" 23 : 255-261, 2003

      14 Park, J.S., "Resveratrol inhibits tumor cell adhension to endothetial cells by blocking ICAM-1 expression" 29 : 355-362, 2009

      15 Stef, G., "Resveratrol inhibits aggregation of platelets from high-risk cardiac patients with aspirin resistance" 48 : 1-5, 2006

      16 Faber, A.C., "Resveratrol induces apoptosis in transformed follicular lymphoma OCI-LY8 cells: evidence for a novel mechanism involving inhibition of BCL6 signaling" 29 : 1561-1566, 2006

      17 Ma, X.D., "Resveratrol induces HepG2 cell apoptosis by depolarizing mitochondrial membrane" 26 : 406-408, 2006

      18 Sun, C., "Resveratrol downregulates the constitutional activation of nuclear factor-kappaB in multiple myeloma cells, leading to suppression of proliferation and invasion, arrest of cell cycle, and induction of apoptosis" 165 : 9-19, 2006

      19 Pillai, R.S., "Repression of protein synthesis by miRNAs: how many mechanisms" 17 : 118-126, 2007

      20 Staudt, L.M., "Regulation of lymphocyte cell fate decisions and lymphomagenesis by BCL-6" 18 : 381-403, 1999

      21 Johnson, S.M., "RAS is regulated by the let-7 microRNA family" 120 : 635-647, 2005

      22 Kundu, J.K., "Molecular basis of chemoprevention by resveratrol: NF-kappaB and AP-1 as potential targets" 555 : 65-80, 2004

      23 Bartel, D.P., "MicroRNAs:genomics,biogenesis,mechanism,and function" 116 : 281-297, 2004

      24 Zhang, B., "MicroRNAs and their regulatory roles in animals and plants" 210 : 279-289, 2007

      25 Nana-Sinkam, S.P., "MicroRNA in lung cancer" 1 : 929-931, 2006

      26 Eder, M., "MicroRNA and lung cancer" 352 : 2446-2448, 2005

      27 Plasterk, R.H., "Micro RNAs in animal development" 124 : 877-881, 2006

      28 Mollerup, S., "Lung carcinogenesis: resveratrol modulates the expression of genes involved in the metabolism of PAH in human bronchial epithelial cells" 92 : 18-25, 2001

      29 Kim, Y.A., "Involvement of p21WAF1/CIP1, pRB, Bax and NFkappaB in induction of growth arrest and apoptosis by resveratrol in human lung carcinoma A549 cells" 23 : 1143-1149, 2003

      30 Rana, T.M., "Illuminating the silence: understanding the structure and function of small RNAs" 8 : 23-36, 2007

      31 Ambros, V., "Identification of microRNAs and other tiny noncoding RNAs by cDNA cloning" 265 : 131-158, 2004

      32 John, B., "Human MicroRNA targets" 2 : 363-, 2004

      33 O’Toole, A.S., "Comprehensive thermodynamic analysis of 3’doublenucleotide overhangs neighboring Watson-Crick terminal pairs" 34 : 3338-3344, 2006

      34 Bhat, K.P., "Cancer chemopreventive activity of resveratrol" 957 : 210-229, 2002

      35 Bhat, K.P.L., "Biological effects of resveratrol" 3 : 1041-1064, 2001

      36 Logarajah, S., "BCL-6 is expressed in breast cancer and prevents mammary epithelial differentiation" 22 : 5572-5578, 2003

      37 Cheng, A.M., "Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis" 33 : 1290-1297, 2005

      38 Schneider, Y., "Anti-proliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells" 158 : 85-91, 2000

      39 He, L., "A microRNA polycistron as a potential human oncogene" 435 : 828-833, 2005

      40 Calin, G.A., "A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia" 353 : 1793-1801, 2005

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2012-11-07 학술지명변경 한글명 : 분자와 세포 -> Molecules and Cells KCI등재
      2008-01-01 평가 SCI 등재 (등재유지) KCI등재
      2006-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2004-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2001-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      1998-07-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 2.77 0.19 1.85
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      1.37 1.11 0.379 0.03
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