Rats treated with high dose of thyroid for 8 days produced a cardiac and renal hypertrophy. The cardiac hypertrophy was proportionately greater than renal hypertrophy. The specific activity of cardiac aldolase was elevated to 178 of that in the contro...
Rats treated with high dose of thyroid for 8 days produced a cardiac and renal hypertrophy. The cardiac hypertrophy was proportionately greater than renal hypertrophy. The specific activity of cardiac aldolase was elevated to 178 of that in the control animals after 9 days of daily hormone treatment, the biggest change seen between the 8th and 9th days of T₃ administration. The rates of synthesis and degradation as determined by the changes in specific radioactivity and total radioactivity, respectively, both fluctuated but in such a way that the net effect was small.