Ligand-Independent Nuclear Degradation of IκB Mediated by Nkx3.2 in Chondrocytes

다국어 초록 (Multilingual Abstract)

During endochondral ossification, a process that accounts for the majority of bone formation in vertebrates, actively growing chondrocytes are initially derived from condensed mesenchymal cells. Later, further differentiated chondrocytes such as pre-hypertrophic and hypertrophic chondrocytes are generated from proliferating chondrocytes through hypertrophic maturation, and the hypertrophic chondrocytes have been shown to be more susceptible to apoptosis compared to the proliferating chondrocytes. We have recently shown that the NF-κB pathway is required for chondrocyte viability, and Nkx3.2 supports chondrocyte survival by constitutively activating Re1A. Furthermore, we have demonstrated that stage-specific NF-κB activation mediated by Nkx3.2 regulates chondrocyte viability during cartilage maturation. In this presentation, molecular mechanisms of ligand-independent nuclear degradation of IkB mediated by Nkx3.2 in chondrocyte will be discussed.