P-30 Association Between Unclassified Interstitial Lung Disease and Mortality = P-30 Association Between Unclassified Interstitial Lung Disease and Mortality

다국어 초록 (Multilingual Abstract)

Background: Unclassified interstitial lung disease is common encounters in clinical practice. However, an association with mortality has not been well studied. We aimed to investigate whether unclassified interstitial lung disease is associated with increased mortality. Methods: National registry data were collected from the Korean National Health Insurance Research Database, comprising 1,025,340 (∼2.2%) random subjects who were selected from 46,605,433 Korean residents in 2002. We also selected subjects self-reported a history of cigarette smoking, more than 40 years old at the entry of cohort. Patients diagnosed with interstitial lung disease in 2002 were excluded. The unclassified ILD patients with an initial diagnosis between January 2003 and December 2007 (n = 783). The comparison group was composed of randomly selected patients (4 per patient with ILD; n = 2601) who were matched to the ILD group in relation to age, sex, residential area, household income, and year of ILD diagnosis. Diagnosis of ILD is based on the International Classification of Disease codes. The study subjects were tracked until 2013. Results: Mortality was 24.3% of the unclassified ILD group and in 5.7% of the comparison group. After adjustment for covariates, unclassified ILD was associated with a higher risk of death (hazard ratio [HR], 1.6 [95%CI, 1.2 to 2.1]; P < .001). The higher rate of mortality was explained by respiratory disease death. Conclusions: Unclassified ILD was associated with a greater risk of all-cause mortality