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      갑상샘눈병증과 연관된 사시의 안정성과 갑상샘자극호르몬 결합억제 면역글로불린과의 연관성 = Relationship between Thyrotropin Binding Inhibitory Immunoglobulin and Strabismus-associated Thyroid Eye Disease Stability

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      https://www.riss.kr/link?id=A108746276

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      Purpose: To investigate the relationship between thyrotropin binding inhibitory immunoglobulin (TBII) and deviation angle stability in strabismus-associated thyroid eye disease.
      Methods: A total of 25 strabismus-associated thyroid eye disease patients who were followed up for > 6 months without surgery were enrolled. To investigate the correlation between TBII levels and changes in the deviation angle, a test period of 6 months from the date of TBII measurement was established and 55 test units of the corresponding TBII levels were obtained.
      Results: The deviation angle had a positive correlation with the TBII levels (r = 0.473, p < 0.001), but did not correlate with sex, age, and thyroid hormone levels. Changes in the horizontal, vertical, and total deviation angles were significantly greater in the high-TBII test units compared to the normal-TBII test units (p = 0.029, = 0.032, and = 0.009, respectively).
      Conclusions: TBII levels were related to deviation angle stability in strabismus-associated thyroid eye disease. TBII may be a useful indicator for deviation angle stability in these patients over a period of 6 months.
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      Purpose: To investigate the relationship between thyrotropin binding inhibitory immunoglobulin (TBII) and deviation angle stability in strabismus-associated thyroid eye disease. Methods: A total of 25 strabismus-associated thyroid eye disease patients...

      Purpose: To investigate the relationship between thyrotropin binding inhibitory immunoglobulin (TBII) and deviation angle stability in strabismus-associated thyroid eye disease.
      Methods: A total of 25 strabismus-associated thyroid eye disease patients who were followed up for > 6 months without surgery were enrolled. To investigate the correlation between TBII levels and changes in the deviation angle, a test period of 6 months from the date of TBII measurement was established and 55 test units of the corresponding TBII levels were obtained.
      Results: The deviation angle had a positive correlation with the TBII levels (r = 0.473, p < 0.001), but did not correlate with sex, age, and thyroid hormone levels. Changes in the horizontal, vertical, and total deviation angles were significantly greater in the high-TBII test units compared to the normal-TBII test units (p = 0.029, = 0.032, and = 0.009, respectively).
      Conclusions: TBII levels were related to deviation angle stability in strabismus-associated thyroid eye disease. TBII may be a useful indicator for deviation angle stability in these patients over a period of 6 months.

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      참고문헌 (Reference)

      1 우경인 ; 김윤덕 ; 이상렬 ; 안성형연구회, "한국인 갑상샘 기능 이상 환자에서 갑상샘눈병증의 임상 특징" 대한안과학회 49 (49): 1387-1396, 2008

      2 채종근 ; 김병진 ; Michael Kazim, "심한 갑상샘연관안와병증과 연관된 위험인자" 대한안과학회 47 (47): 1238-1243, 2006

      3 임원일 ; 최승식 ; 유혜린 ; 윤영수, "갑상선 안병증과 갑상선 기능상태의 연관성" 대한안과학회 43 (43): 1-436, 2002

      4 곽지영 ; 이동철, "갑상샘눈병증에서 갑상샘자극항체 수치 변화에 따른 외안근 두께 변화의 상관관계 분석" 대한안과학회 62 (62): 1315-1323, 2021

      5 황덕진 ; 김윤정, "갑상샘눈병증과 혈청 자가항체의 관련성에 관한 연구" 대한안과학회 51 (51): 1167-1173, 2010

      6 이연희 ; 황정민 ; 오세열, "갑상샘눈병증과 관련된 사시의 자연경과" 대한안과학회 47 (47): 1993-1998, 2006

      7 Kazuo K, "Value of thyroid stimulating antibody in the diagnosis of thyroid associated ophthalmopathy of euthyroid patients" 81 : 1080-1083, 1997

      8 Smith BR, "Thyroid-stimulating immunoglobulins in Graves'disease" 2 : 427-431, 1974

      9 Goh SY, "Thyroid autoantibody profiles in ophthalmic dominant and thyroid dominant Graves' disease differ and suggest ophthalmopathy is a multiantigenic disease" 60 : 600-607, 2004

      10 Kavoussi SC, "The relationship between sex and symmetry in thyroid eye disease" 8 : 1295-1300, 2014

      1 우경인 ; 김윤덕 ; 이상렬 ; 안성형연구회, "한국인 갑상샘 기능 이상 환자에서 갑상샘눈병증의 임상 특징" 대한안과학회 49 (49): 1387-1396, 2008

      2 채종근 ; 김병진 ; Michael Kazim, "심한 갑상샘연관안와병증과 연관된 위험인자" 대한안과학회 47 (47): 1238-1243, 2006

      3 임원일 ; 최승식 ; 유혜린 ; 윤영수, "갑상선 안병증과 갑상선 기능상태의 연관성" 대한안과학회 43 (43): 1-436, 2002

      4 곽지영 ; 이동철, "갑상샘눈병증에서 갑상샘자극항체 수치 변화에 따른 외안근 두께 변화의 상관관계 분석" 대한안과학회 62 (62): 1315-1323, 2021

      5 황덕진 ; 김윤정, "갑상샘눈병증과 혈청 자가항체의 관련성에 관한 연구" 대한안과학회 51 (51): 1167-1173, 2010

      6 이연희 ; 황정민 ; 오세열, "갑상샘눈병증과 관련된 사시의 자연경과" 대한안과학회 47 (47): 1993-1998, 2006

      7 Kazuo K, "Value of thyroid stimulating antibody in the diagnosis of thyroid associated ophthalmopathy of euthyroid patients" 81 : 1080-1083, 1997

      8 Smith BR, "Thyroid-stimulating immunoglobulins in Graves'disease" 2 : 427-431, 1974

      9 Goh SY, "Thyroid autoantibody profiles in ophthalmic dominant and thyroid dominant Graves' disease differ and suggest ophthalmopathy is a multiantigenic disease" 60 : 600-607, 2004

      10 Kavoussi SC, "The relationship between sex and symmetry in thyroid eye disease" 8 : 1295-1300, 2014

      11 Khoo DH, "The combination of absent thyroid peroxidase antibodies and high thyroid-stimulating immunoglobulin levels in Graves' disease identifies a group at markedly increased risk of ophthalmopathy" 9 : 1175-1180, 1999

      12 Boergen KP, "Surgical repair of motility impairment in Graves’orbitopathy" 20 : 159-168, 1989

      13 Long JC, "Surgical management of the tropias of thyroid exophthalmos" 75 : 634-638, 1966

      14 Schotthoefer EO, "Strabismus associated with thyroid eye disease" 18 : 361-365, 2007

      15 Xing L, "Smoking was associated with poor response to intravenous steroids therapy in Graves’ ophthalmopathy" 99 : 1686-1691, 2015

      16 Stein JD, "Risk factors for developing thyroid-associated ophthalmopathy among individuals with Graves disease" 133 : 290-296, 2015

      17 Wall JR, "Relationship between clinical and immunological features of thyroid autoimmunity and ophthalmopathy during pregnancy" 2015 : 698470-, 2015

      18 Choi JH, "Prognostic factors of restrictive myopathy in thyroid eye disease" 11 : 13781-, 2021

      19 Khoo TK, "Pathogenesis of Graves' ophthalmopathy : the role of autoantibodies" 17 : 1013-1018, 2007

      20 Utiger RD, "Pathogenesis of Graves' ophthalmopathy" 326 : 1772-1773, 1992

      21 Lee YH, "Is 6 months of stable angle of strabismus enough to perform surgery in patients with strabismus related to thyroid ophthalmopathy?" 94 : 955-956, 2010

      22 Bahn RS, "Graves' ophthalmopathy" 362 : 726-738, 2010

      23 Smith TJ, "Graves' disease" 375 : 1552-1565, 2016

      24 Coats DK, "Early strabismus surgery for thyroid ophthalmopathy" 106 : 324-329, 1999

      25 Regensburg NI, "Do subtypes of Graves' orbitopathy exist?" 118 : 191-196, 2011

      26 장선영 ; 신동엽 ; 이은직 ; 최영준 ; 이상렬 ; 윤진숙, "Correlation between TSH Receptor Antibody Assays and Clinical Manifestations of Graves’ Orbitopathy" 연세대학교의과대학 54 (54): 1033-1039, 2013

      27 Metz HS, "Complications following surgery for thyroid ophthalmopathy" 21 : 220-222, 1984

      28 Bartley GB, "Clinical features of Graves' ophthalmopathy in an incidence cohort" 121 : 284-290, 1996

      29 Thornton J, "Cigarette smoking and thyroid eye disease : a systematic review" 21 : 1135-1145, 2007

      30 Ben Simon GJ, "Age differences in clinical manifestation and prognosis of thyroid eye disease" 253 : 2301-2308, 2015

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