홍고추가루 수용성 추출물의 항염증 효과

국문 초록 (Abstract)

본 연구의 목적은 향신료로서 한국인의 식생활에 중요한 위치를 차지하고 있는 홍고추가루 수용성 추출물의 항염증 활성을 검토해보고자 수행되었다. 그 결과 홍고추가루의 수용성 추출물은 LPS 처리에 의한 NO 및 PGE₂의 생성을 현저히 억제시키는 것을 관찰할 수 있었으며, NO의 생합성효소인 iNOS 단백질의 발현 또한 억제시킴을 확인할 수 있었다. 홍고추가루의 수용성 추출물은 염증성 사이토카인인 IL-6의 생성억제 효과도 탁월하였다. 이러한 연구결과로 볼 때 고추의 수용성 추출물이 대식세포에 의해 생성되는 염증반응의 매개물질인 NO, PGE₂, IL-6의 생성을 억제함으로 염증반응을 완화시켜 주는 것으로 판단된다. 차후 항염증 활성을 갖는 홍고추가루의 수용성 추출물의 성분을 동정하는 연구가 필요할 것으로 사료되며, 고추가 식품유래의 항염증 활성을 갖는 제품 개발에 있어 유용한 식품자원 원료로 사용될 수 있을 것으로 생각된다.

다국어 초록 (Multilingual Abstract)

Inflammation is a pivotal component of a variety of diseases, such as atherosclerosis and tumour progression. Various naturally occurring phytochemicals exhibit antiinflammatory activity and are considered to be potential drug candidates against inflammation-related pathological processes. Red pepper is the most consumed species in Korea. However, the antiinflammatory effects of red pepper have not been characterized. Thus, the present study was designed to evaluate the effects of the aqueous extract from red pepper (RPAE) on lipopolysaccharide (LPS)-induced inflammatory responses in murine macrophages. RPAE demonstrated strong antiinflammatory activity through its ability to reduce nitric oxide and prostaglandin E2 production in the LPS-stimulated mouse macrophage cell, RAW264.7. It also inhibited the production of interleukin-6 (IL-6) on the LPS-stimulated RAW264.7 cells. Further study indicated that LPS-stimulated induction of inducible nitric oxide synthase and cyclooxygenase-2 was significantly inhibited by RPAE exposure (1,000 ㎎/mL) in RAW264.7 cells. Collectively, these data suggest that the use of RPAE may be a useful therapeutic approach to various inflammatory diseases.

목차 (Table of Contents)

• Abstract
• 서론
• 재료 및 방법
• 결과 및 고찰
• 요약
• 감사의 글
• 문헌

참고문헌 (Reference)

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