肥滿과 血淸 Insulin値에 關하여 = Study on the Obesity and Serum Insulin

다국어 초록 (Multilingual Abstract)

The correlation between obesity and the serum insulin level were studied in 10 healthy adults, 18 non-diabetic patients without edema and 25 diabetic patients. Among all 53 cases, there were 19 cases of obesity by Suh's criteria of Korean ideal body weigh (more than 20% of ideal weight). The serum insulin and blood glucose at fasting and dureing 100g oral glucose tolerance test were measured. Serum insulin was measured by method of Solid phase125 Radioimmunoassay (Coat-A-Count Tnsulin Kit)-
The results were as follows:
1. Inhealthy adult, the level of fasting serum insulin was average 3.1μU/ml in on-obese, 16.5 μU/ml in obese adults, The insulin level in 30 minutes after GTT, was 45.8 μU/ml in non-obese and 145.5 μU/ml in obese adults. These data showed that hyperinsulinemia occurs in non-diabetic obesity either in fasting or after the glucose loading.
2. In nondiabetic patients without edema, the serum insulin level were average 20.3μU/ml in fasting, 61.4 μU/ml after 30 minutes, 100.7 μU/ml after 60 minutes, 118,7 μU/ml after 120 minutes and 52.8 μU/ml after 180 minutes in non-obese patients. In obese patients, the serum insulin level were average 30.9 μU/ml, 109.0 μU/ml after 30 minutes, 119.3 μU/ml after 60 minutes, 146.3 μU/ml after 120 minutes and 82.5 μU/ml after 180 minutes. These data showed the serum insulin level increased clearly but delayed than normal adult in obses patients.
3. The correlation between obesity index (body wt/ideal body wt) and fasting serum insulin. level were studied. The coefficient of correlation was 0.88 in healthy adults and 0.96 in non-obese patients. These data showed that serum insulin level is not only related to obesity but also body weight.
4. In diabetic patients, the fasting serum insulin level was as same as non-diabetic healthy adult or patient. There was no difference of serum insulin between obses and non-obese diabetic patients. It appeared slightly higher increase of serum insulin by GTT in obses than non-obses diabetic patients but there was no statistical significance in the difference. There was no correlation between serum insulin level and obesity index (coefficient of correlation 0.3) in diabetic patients.