Parkinson's disease : molecular mechanisms underlying pathology

목차 (Table of Contents)

• CONTENTS
• List of Contributors = ix
• Preface = xi
• 1 The Neurogenetics of Parkinson's Disease and Putative Links to Other Neurodegenerative Disorders / C.M. Lill ; C. Klein
• 1 Introduction = 2
• 2 Definition of (Genetic) Parkinson's Disease = 4
• 3 Classification and Nomenclature of Monogenic Parkinson's Disease = 5
• 4 Monogenic Forms of Parkinson's Disease and Parkinsonism = 6
• 5 PARK-SNCA = 11
• 6 PARK-LRRK2 = 12
• 7 PARK-VPS35 = 12
• 8 PARK-Parkin = 13
• 9 PARK-PINK1 = 13
• 10 PARK-DJ-1 = 14
• 11 Recent Novel Parkinson's Disease Candidate Genes = 14
• 12 Systematic and Regularly Updated Overview of Parkirison's Disease Mutations = 14
• 13 Reduced Penetrance and Variable Expressivity of Genetic Parkinson's Disease = 15
• 14 Genetic Association Studies = 16
• 15 Candidate Gene Studies in Parkinson's Disease = 17
• 16 Genome-Wide Association Studies = 22
• 17 Gene-Environment Interactions in Parkinson's Disease = 28
• 18 Lessons Learned From Other Monogenic Neurodegenerative Diseases = 29
• 19 Translational Genetics : From Animal Models to Personalized Treatments = 29
• 20 Most Important Questions for Future Perspectives of PD Neurogenetics = 32
• References = 33
• 2 Electron Transport Chain / L. Aerts ; V.A. Morais
• 1 Introduction = 42
• 2 Glycolysis in the Cytosol = 42
• 3 Impact of Electron Transport Chain Dysfunction on Neuronal Function = 48
• 4 What Have The Genetics Taught Us About Electron Transport Chain Dysfunction and the Sporadic Forms of Parkinson's Disease? = 53
• 5 Correlation Between Findings Obtained Using Different Animal Models = 58
• 6 Therapeutic Pathways Targeting the Electron Transport Chain = 63
• 7 Conclusions = 66
• References = 67
• 3 Mitochondrial Fission and Fusion / V.L. Hewitt ; A.J. Whitworth
• 1 Introduction = 78
• 2 Fission and Fusion Machinery = 80
• 3 Functions of Fission and Fusion in Neurons = 82
• 4 Fission and Fusion is Linked to Neurodegeneration = 84
• 5 PD Genes and Mitochondrial Morphology = 85
• 6 Mitochondrial Dynamics and Mitochondrial Turnover = 93
• 7 Therapeutic Potential of Targeting Fission and Fusion = 96
• 8 Conclusions = 98
• References = 98
• 4 Axonal Mitochondrial Transport / E. Shlevkov ; T.L. Schwarz
• 1 Prelude = 113
• 2 On the Distribution of Power : Mitochondria to Match Supply and Demand = 115
• 3 Mitochondrial Movement is Essential for Maintaining a Healthy Mitochondrial Population in Neurons = 117
• 4 A Motor/Adaptor Complex Enables and Regulates Mitochondrial Trafficking = 122
• 5 Linking PD and Mitochondrial Transport : Mitochondrial Dysfunction Causes Mitochondrial Arrest = 124
• 6 Do Other Forms of PD Involve Defects in Mitochondrial Movement? = 128
• 7 Summary : The Virtuous and Vicious Cycles that Link Mitochondrial Transport and Mitochondrial Health = 130
• References = 131
• 5 Mitophagy / L. King ; H. Plun-Favreau
• 1 Introduction = 140
• 2 Mitochondrial Quality Control = 140
• 3 PINK1 and Parkin = 144
• 4 PINK1-Parkin-Mediated Mitophagy = 149
• 5 PINK1 and/or Parkin-Independent Selective Mitophagy = 156
• 6 Methods to Detect Mitophagy = 157
• 7 Outstanding Questions = 163
• References = 166
• 6 Autophagy / P.A. Lewis ; M. Perez-Carrion ; G. Piccoli
• 1 Introduction = 179
• 2 Lessons From the Genetics of Parkinsons Disease = 181
• 3 Ageing and Autophagy = 188
• 4 Autophagy in the Nervous System : Friend or Foe? = 190
• 5 Autophagy Induction to Promote Neuronal Survival = 194
• 6 Conclusions = 198
• References = 198
• 7 Endocytosis and Synaptic Function / S.F. Soukup ; P. Verstreken ; S. Vilain
• 1 Introduction = 207
• 2 The Synaptic Vesicle Cycle and PD = 208
• 3 Exosome Release = 230
• 4 Summary = 233
• References = 234
• 8 Neuroinflammation as a Potential Mechanism Underlying Parkinsons Disease / C. Cebrian ; D. Sulzer
• 1 Introduction = 246
• 2 The Role of Glial Cells in PD = 248
• 3 Involvement of Proinflammatory Substances and Oxidative Stress in PD = 251
• 4 Infiltration of Lymphocytes in PD = 252
• 5 Involvement of PD-related Genes in Neuroinflammation = 255
• 6 Potential Antiinflammatory Treatments for PD = 261
• 7 Summary and Conclusions = 264
• References = 265
• 9 Protein Translation in Parkinson's Disease / J.W. Kim ; L. Abalde-Atristain ; H. Jia ; I. Martin ; T.M. Dawson ; V.L. Dawson
• 1 Protein Translation and its Regulation in Neurons = 282
• 2 PD-Linked Mutations and Their Impact on Protein Translation = 286
• 3 Protein Translation and Neurotoxicity in Parkinson's Disease = 295
• 4 Future Directions = 302
• References = 304
• Index = 311