抗癌劑(Nitrogen Mustard, Methotrexate, 5-Fluorouracil)가 肝再生, 皮膚創傷治癒 및 骨髓에 미치는 影響 = Influence of Anticancerous Agents (Nitrogen Mustard, Methotrexate, 5-Fluorouracil) on Hepatic Regeneration, Wound Healing and Bone Marrow

다국어 초록 (Multilingual Abstract)

Although it is still far from the goal, a great advance has been made in the field of cancer chemotherapy during the past decade, and numerous chemical and biological agents have been proved to have anticancerous effects.
At present, anticancerous agents can be divided into 6 major groups: 1) Alkylating agents, 2) Antimetabolites, 3) Antibiotics, 4) Hormones, 5) Radioisotopes, and 6) Other miscellaneous agents. Some of the agents act rather selectively to certain cells, while others affect by virtue of their cytotoxic and antimetabolic action(Goodman and Gilman 1965).
Because of many common metabolic pathways between cancer cells and normal cells, many anticancerous drugs accompany untoward effect to normal tissue as well, especially to those actively regenerating tissues such as bone marrow, intestinal epithelium, fetal tissue, etc. (Heiderberger et al. 1957, Cantarow et al. 1958, Paschkis et al. 1959). Therefore, the dose of anticancerous agents has to be strictly controlled.
In clinical practice, chemotherapeutic agents are applied mostly in palliative purposes rather than radical treatment in the patient of disseminated cancer. However, recently, chemotherapeutic agents are being used for the radical treatment by regional perfusion technique (Clarkson and Lawrence 1961), or in purpose of obtaining shrinkage of a large tumor to enable to operate radically. Furthermore, it is being attempted to use chemotherapeutic agents in adjuvant to the cancer surgery to prevent spread of tumor cells and destroy possible residual tumor cells at the surgery (Moore and Kondo 1958, McDonald 1960).
Present investigation is designed to study the influence of nitrogen mustard, methotrexate, and 5-fluorouracil on wound healing, regeneration of the liver, and the regeneration of the bone marrow when these drugs are administered in combination with a surgical procedure.