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      증 례 : 직장암 치료 중 진단된 만성호중구성백혈병 1예 = Case Reports : Incidentally Found Chronic Neutrophilic Leukemia in a Patient with Rectal Cancer

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      https://www.riss.kr/link?id=A101720968

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      다국어 초록 (Multilingual Abstract)

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      Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm characterized by sustained neutrophilia, splenomegaly, and hypercellular bone marrow without Philadelphia chromosome. Diagnosis of CNL requires exclusion of identifiable causes of reactive neutrophilia, such as infection and tumors. Our patient presented with general weakness and weight loss. Computed tomography (CT) showed a mass in the distal rectum, which was confirmed to be an adenocarcinoma by colonoscopic biopsy. Positron emission tomography-CT showed multiple liver, bone, and lymph node metastases. Liver and lymph node biopsies revealed neutrophilic infiltration with no evidence of adenocarcinoma. The pathological findings of the bone marrow were compatible with CNL. Cytogenetic analysis revealed a normal karyotype, and molecular analysis was negative for BCR/ABL. Here, we present a 73 year-old man diagnosed with concurrent CNL and rectal cancer. (Korean J Med 2016;90:59-62)
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      Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm characterized by sustained neutrophilia, splenomegaly, and hypercellular bone marrow without Philadelphia chromosome. Diagnosis of CNL requires exclusion of identifiable causes ...

      Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm characterized by sustained neutrophilia, splenomegaly, and hypercellular bone marrow without Philadelphia chromosome. Diagnosis of CNL requires exclusion of identifiable causes of reactive neutrophilia, such as infection and tumors. Our patient presented with general weakness and weight loss. Computed tomography (CT) showed a mass in the distal rectum, which was confirmed to be an adenocarcinoma by colonoscopic biopsy. Positron emission tomography-CT showed multiple liver, bone, and lymph node metastases. Liver and lymph node biopsies revealed neutrophilic infiltration with no evidence of adenocarcinoma. The pathological findings of the bone marrow were compatible with CNL. Cytogenetic analysis revealed a normal karyotype, and molecular analysis was negative for BCR/ABL. Here, we present a 73 year-old man diagnosed with concurrent CNL and rectal cancer. (Korean J Med 2016;90:59-62)

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      참고문헌 (Reference)

      1 Vardiman J, "World health organization classification, evaluation, and genetics of the myeloproliferative neoplasm variants" 2011 : 250-256, 2011

      2 Swerdlow SH, "WHO classification of tumours of haematopoetic and lymphoid tissues" IARC Press 2008

      3 Gotlib J, "The new genetics of chronic neutrophilic leukemia and atypical CML : implications for diagnosis and treatment" 122 : 1707-1711, 2013

      4 Maxson JE, "Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML" 368 : 1781-1790, 2013

      5 Böhm J, "Evidence of clonality in chronic neutrophilic leukaemia" 56 : 292-295, 2003

      6 Neureiter D, "Differential diagnostic challenge of chronic neutrophilic leukemia in a patient with prolonged leukocytosis" 1 : 23-27, 2008

      7 Reilly JT, "Chronic neutrophilic leukaemia : a distinct clinical entity?" 116 : 10-18, 2002

      8 Sakka V, "An update on the etiology and diagnostic evaluation of a leukemoid reaction" 17 : 394-398, 2006

      1 Vardiman J, "World health organization classification, evaluation, and genetics of the myeloproliferative neoplasm variants" 2011 : 250-256, 2011

      2 Swerdlow SH, "WHO classification of tumours of haematopoetic and lymphoid tissues" IARC Press 2008

      3 Gotlib J, "The new genetics of chronic neutrophilic leukemia and atypical CML : implications for diagnosis and treatment" 122 : 1707-1711, 2013

      4 Maxson JE, "Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML" 368 : 1781-1790, 2013

      5 Böhm J, "Evidence of clonality in chronic neutrophilic leukaemia" 56 : 292-295, 2003

      6 Neureiter D, "Differential diagnostic challenge of chronic neutrophilic leukemia in a patient with prolonged leukocytosis" 1 : 23-27, 2008

      7 Reilly JT, "Chronic neutrophilic leukaemia : a distinct clinical entity?" 116 : 10-18, 2002

      8 Sakka V, "An update on the etiology and diagnostic evaluation of a leukemoid reaction" 17 : 394-398, 2006

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2023 평가예정 계속평가 신청대상 (계속평가)
      2021-01-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
      2018-12-01 평가 등재후보 탈락 (계속평가)
      2017-12-01 평가 등재후보로 하락 (계속평가) KCI등재후보
      2013-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2010-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2008-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2006-05-15 학술지명변경 외국어명 : Korean Journal of Medicine -> The Korean Journal of Medicine KCI등재
      2006-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2003-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2002-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2000-07-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.1 0.1 0.1
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.11 0.1 0.259 0.02
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