만성 간질환 환자에서 Phospholipase A2 활성도 = Serum Phospholipase A2 Activities in Patients with Chronic Liver Disease

다국어 초록 (Multilingual Abstract)

Background / Purpose : Phospholipase A2(PLA2) is an rate-limiting enzyme hydrolyzing arachidonic and from the sn-2 position of membrane Phospholipida. In vitro studies demonstrated that the enzyme could be secreted into extracellular mileu by pro-infalmmatory cytokines and endotoxin which were reported to have important role s in chronic liver diseases . Methods : The subjects were composed of 24 patients with chronic hepatitis B, 26 patients with liver cirrhosis and radioactivity of 14C-fatty acid hydrolyzed from 14C - labled phosphotadylethanolamine by the enzyme. Results : The activities of PLA2 were increased in the patients with chronic liver diseases, especially in the chronic hepatitis B patients with acute exacerbation and in the decompensated cirrhosis patients. Furthermore, their activities were closely related with the levels of transaminase in hepatitis group and with the levels of serum albumin in cirrhosis group, respectively. Conclusions : These results suggest that extracellur PLA2 might be involved in the exacerbation and progression of the chronic liver diseases.