1 Kageyama H, "Visualization of ghrelin-producing neurons in the hypothalamic arcuate nucleus using ghrelin-EGFP transgenic mice" 145 : 116-121, 2008
2 Toshinai K, "Upregulation of ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration" 281 : 1220-1225, 2001
3 최철수, "Uncoupling Protein-2 Decreases the Lipogenic Actions of Ghrelin" ENDOCRINE SOC 151 (151): 2078-2086, 201005
4 Gauna C, "Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor" 251 : 103-111, 2006
5 Andrews ZB, "UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals" 454 : 846-851, 2008
6 Ariyasu H, "Transgenic mice overexpressing des-acyl ghrelin show small phenotype" 146 : 355-364, 2005
7 Raff H, "Total and active ghrelin in developing rats during hypoxia" 21 : 159-161, 2003
8 Rindi G, "The “normal” endocrine cell of the gut: changing concepts and new evidences" 1014 : 1-12, 2004
9 Gnanapavan S, "The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans" 87 : 2988-, 2002
10 Date Y, "The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats" 123 : 1120-1128, 2002
11 Wren AM, "The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion" 141 : 4325-4328, 2000
12 Suzuki K, "The gut hormones in appetite regulation" 2011 : 528401-, 2011
13 Cowley MA, "The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis" 37 : 649-661, 2003
14 Kojima M, "The discovery of ghrelin: with a little luck and great passion. Preface" 32 : 2153-2154, 2011
15 García-Galiano D, "The anorexigenic neuropeptide, nesfatin-1, is indispensable for normal puberty onset in the female rat" 30 : 7783-7792, 2010
16 Yosten GL, "The anorexigenic and hypertensive effects of nesfatin-1 are reversed by pretreatment with an oxytocin receptor antagonist" 298 : R1642-R1647, 2010
17 Stengel A, "The RAPID method for blood processing yields new insight in plasma concentrations and molecular forms of circulating gut peptides" 150 : 5113-5118, 2009
18 Guan JL, "Synaptic interactions between ghrelin- and neuropeptide Y-containing neurons in the rat arcuate nucleus" 24 : 1921-1928, 2003
19 Bednarek MA, "Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a" 43 : 4370-4376, 2000
20 Asakawa A, "Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin" 54 : 15-24, 2005
21 Ariyasu H, "Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans" 86 : 4753-4758, 2001
22 Shimada M, "Somatostatin suppresses ghrelin secretion from the rat stomach" 302 : 520-525, 2003
23 Pfluger PT, "Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure" 294 : G610-G618, 2008
24 Nonogaki K, "Serotonin systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors and induce anorexia via a leptin-independent pathway in mice" 372 : 186-190, 2008
25 de la Cour CD, "Secretion of ghrelin from rat stomach ghrelin cells in response to local microinfusion of candidate messenger compounds: a microdialysis study" 143 : 118-126, 2007
26 Tabarin A, "Role of the corticotropin-releasing factor receptor type 2 in the control of food intake in mice: a meal pattern analysis" 26 : 2303-2314, 2007
27 Zhang JV, "Response to Comment on “Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin’s Effects on Food Intake”" 315 : 766d-, 2007
28 Hiejima H, "Regional distribution and the dynamics of n-decanoyl ghrelin, another acyl-form of ghrelin, upon fasting in rodents" 156 : 47-56, 2009
29 Fischer T, "Reassessment of sst2 somatostatin receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-1" 93 : 4519-4524, 2008
30 Madison LD, "Prostacyclin signaling regulates circulating ghrelin during acute inflammation" 196 : 263-273, 2008
31 Tschöp M, "Post-prandial decrease of circulating human ghrelin levels" 24 : RC19-RC21, 2001
32 Ogiso K, "Plasma nesfatin-1 concentrations in restricting-type anorexia nervosa" 32 : 150-153, 2011
33 Cummings DE, "Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery" 346 : 1623-1630, 2002
34 Kobelt P, "Peripheral obestatin has no effect on feeding behavior and brain Fos expression in rodents" 29 : 1018-1027, 2008
35 Wang L, "Peripheral ghrelin selectively increases Fos expression in neuropeptide Y - synthesizing neurons in mouse hypothalamic arcuate nucleus" 325 : 47-51, 2002
36 Shimizu H, "Peripheral administration of nesfatin-1 reduces food intake in mice: the leptin-independent mechanism" 150 : 662-671, 2009
37 Iwakura H, "Oxytocin and dopamine stimulate ghrelin secretion by the ghrelin-producing cell line, MGN3-1 in vitro" 152 : 2619-2625, 2011
38 Chen HY, "Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein" 145 : 2607-2612, 2004
39 Tsolakis AV, "Obestatin/ghrelin cells in normal mucosa and endocrine tumours of the stomach" 160 : 941-949, 2009
40 Zhang JV, "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake" 310 : 996-999, 2005
41 Lagaud GJ, "Obestatin reduces food intake and suppresses body weight gain in rodents" 357 : 264-269, 2007
42 Zizzari P, "Obestatin partially affects ghrelin stimulation of food intake and growth hormone secretion in rodents" 148 : 1648-1653, 2007
43 Bresciani E, "Obestatin inhibits feeding but does not modulate GH and corticosterone secretion in the rat" 29 : RC16-RC18, 2006
44 Zhang JV, "Obestatin induction of early-response gene expression in gastrointestinal and adipose tissues and the mediatory role of G protein-coupled receptor, GPR39" 22 : 1464-1475, 2008
45 Carlini VP, "Obestatin improves memory performance and causes anxiolytic effects in rats" 352 : 907-912, 2007
46 Lauwers E, "Obestatin does not activate orphan G protein-coupled receptor GPR39" 351 : 21-25, 2006
47 Samson WK, "Obestatin acts in brain to inhibit thirst" 292 : R637-R643, 2007
48 Gourcerol G, "Obestatin - a ghrelin-associated peptide that does not hold its promise to suppress food intake and motility" 19 : 161-165, 2007
49 Tremblay F, "Normal food intake and body weight in mice lacking the G protein-coupled receptor GPR39" 148 : 501-506, 2007
50 Zorrilla EP, "Nibbling at CRF receptor control of feeding and gastrocolonic motility" 24 : 421-427, 2003
51 Brailoiu GC, "Nesfatin-1: distribution and interaction with a G protein-coupled receptor in the rat brain" 148 : 5088-5094, 2007
52 Shimizu H, "Nesfatin-1: an overview and future clinical application" 56 : 537-543, 2009
53 Stengel A, "Nesfatin-1: a novel inhibitory regulator of food intake and body weight" 12 : 261-271, 2011
54 Maejima Y, "Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway" 10 : 355-365, 2009
55 Kohno D, "Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding" 149 : 1295-1301, 2008
56 Price CJ, "Nesfatin-1 inhibits NPY neurons in the arcuate nucleus" 1230 : 99-106, 2008
57 Yosten GL, "Nesfatin-1 exerts cardiovascular actions in brain: possible interaction with the central melanocortin system" 297 : R330-R336, 2009
58 Iwasaki Y, "Nesfatin-1 evokes Ca2+ signaling in isolated vagal afferent neurons via Ca2+ influx through N-type channels" 390 : 958-962, 2009
59 Yamamoto D, "Neither intravenous nor intracerebroventricular administration of obestatin affects the secretion of GH, PRL, TSH and ACTH in rats" 138 : 141-144, 2007
60 Gonzalez R, "Molecular, cellular and physiological evidences for the anorexigenic actions of nesfatin-1 in goldfish" 5 : e15201-, 2010
61 Zigman JM, "Mice lacking ghrelin receptors resist the development of diet-induced obesity" 115 : 3564-3572, 2005
62 Unniappan S, "Metabolic effects of chronic obestatin infusion in rats" 29 : 1354-1361, 2008
63 Strassburg S, "Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in rats" 295 : E78-E84, 2008
64 Mizutani M, "Localization of acyl ghrelin- and des-acyl ghrelin-immunoreactive cells in the rat stomach and their responses to intragastric pH" 297 : G974-G980, 2009
65 Stengel A, "Lipopolysaccharide differentially decreases plasma acyl and desacyl ghrelin levels in rats: potential role of the circulating ghrelin-acylating enzyme GOAT" 31 : 1689-1696, 2010
66 Schellekens H, "Lean mean fat reducing “ghrelin” machine: hypothalamic ghrelin and ghrelin receptors as therapeutic targets in obesity" 58 : 2-16, 2010
67 Gourcerol G, "Lack of obestatin effects on food intake: should obestatin be renamed ghrelin-associated peptide (GAP)?" 141 : 1-7, 2007
68 Gourcerol G, "Lack of interaction between peripheral injection of CCK and obestatin in the regulation of gastric satiety signaling in rodents" 27 : 2811-2819, 2006
69 Inhoff T, "Is desacyl ghrelin a modulator of food intake?" 30 : 991-994, 2009
70 Brennan IM, "Intravenous CCK-8, but not GLP-1, suppresses ghrelin and stimulates PYY release in healthy men" 28 : 607-611, 2007
71 Davenport AP, "International Union of Pharmacology. LVI. Ghrelin receptor nomenclature, distribution, and function" 57 : 541-546, 2005
72 Saad MF, "Insulin regulates plasma ghrelin concentration" 87 : 3997-4000, 2002
73 Nishi Y, "Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin" 146 : 2255-2264, 2005
74 González CR, "Influence of chronic undernutrition and leptin on GOAT mRNA levels in rat stomach mucosa" 41 : 415-421, 2008
75 Lu S, "Immunocytochemical observation of ghrelin-containing neurons in the rat arcuate nucleus" 321 : 157-160, 2002
76 Cassoni P, "Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines" 86 : 1738-1745, 2001
77 Yang J, "Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone" 132 : 387-396, 2008
78 Ramanjaneya M, "Identification of nesfatin-1 in human and murine adipose tissue: a novel depot-specific adipokine with increased levels in obesity" 151 : 3169-3180, 2010
79 Oh-I S, "Identification of nesfatin-1 as a satiety molecule in the hypothalamus" 443 : 709-712, 2006
80 Stengel A, "Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosa" 150 : 232-238, 2009
81 López M, "Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin" 7 : 389-399, 2008
82 Holst B, "High constitutive signaling of the ghrelin receptor - identification of a potent inverse agonist" 17 : 2201-2210, 2003
83 Arnold M, "Gut vagal afferents are not necessary for the eating-stimulatory effect of intraperitoneally injected ghrelin in the rat" 26 : 11052-11060, 2006
84 Sakata I, "Growth hormone secretagogue receptor expression in the cells of the stomach-projected afferent nerve in the rat nodose ganglion" 342 : 183-186, 2003
85 Hagemann D, "Glucagon-like peptide 1 (GLP-1) suppresses ghrelin levels in humans via increased insulin secretion" 143 : 64-68, 2007
86 Kojima M, "Ghrelin: structure and function" 85 : 495-522, 2005
87 Sakata I, "Ghrelin-producing cells exist as two types of cells, closed- and opened-type cells, in the rat gastrointestinal tract" 23 : 531-536, 2002
88 Soares JB, "Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle" 29 : 1255-1270, 2008
89 Date Y, "Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans" 141 : 4255-4261, 2000
90 Sun Y, "Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor" 101 : 4679-4684, 2004
91 Els S, "Ghrelin receptor: high constitutive activity and methods for developing inverse agonists" 485 : 103-121, 2010
92 Wang L, "Ghrelin prevents levodopa-induced inhibition of gastric emptying and increases circulating levodopa in fasted rats" 2012
93 Gutierrez JA, "Ghrelin octanoylation mediated by an orphan lipid transferase" 105 : 6320-6325, 2008
94 Date Y, "Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion" 51 : 124-129, 2002
95 Kojima M, "Ghrelin is a growth-hormone-releasing acylated peptide from stomach" 402 : 656-660, 1999
96 Tschöp M, "Ghrelin induces adiposity in rodents" 407 : 908-913, 2000
97 Davies JS, "Ghrelin induces abdominal obesity via GHS-R-dependent lipid retention" 23 : 914-924, 2009
98 Druce MR, "Ghrelin increases food intake in obese as well as lean subjects" 29 : 1130-1136, 2005
99 Chen CY, "Ghrelin gene products and the regulation of food intake and gut motility" 61 : 430-481, 2009
100 Hosoda H, "Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue" 279 : 909-913, 2000
101 Jiang H, "Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimers" 20 : 1772-1785, 2006
102 Theander-Carrillo C, "Ghrelin action in the brain controls adipocyte metabolism" 116 : 1983-1993, 2006
103 Xu G, "Gastric mammalian target of rapamycin signaling regulates ghrelin production and food intake" 150 : 3637-3644, 2009
104 Holst B, "GPR39 signaling is stimulated by zinc ions but not by obestatin" 148 : 13-20, 2007
105 Kirchner H, "GOAT links dietary lipids with the endocrine control of energy balance" 15 : 741-745, 2009
106 Hattori N, "GH, GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils" 86 : 4284-4291, 2001
107 Nagaraj S, "Fragments of obestatin as modulators of feed intake, circulating lipids, and stored fat" 366 : 731-737, 2008
108 Li QC, "Fasting plasma levels of nesfatin-1 in patients with type 1 and type 2 diabetes mellitus and the nutrient-related fluctuation of nesfatin-1 level in normal humans" 159 : 72-77, 2010
109 Tsuchiya T, "Fasting concentrations of nesfatin-1 are negatively correlated with body mass index in non-obese males" 73 : 484-490, 2010
110 Banks WA, "Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure" 302 : 822-827, 2002
111 Cassoni P, "Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines" 150 : 173-184, 2004
112 García-Galiano D, "Expanding roles of NUCB2/nesfatin-1 in neuroendocrine regulation" 45 : 281-290, 2010
113 Pérez-Tilve D, "Exendin-4 potently decreases ghrelin levels in fasting rats" 56 : 143-151, 2007
114 Xu L, "Evidence for the presence of motilin, ghrelin, and the motilin and ghrelin receptor in neurons of the myenteric plexus" 124 : 119-125, 2005
115 Thanthan S, "Endogenous ghrelin released in response to endothelin stimulates growth hormone secretion in cattle" 38 : 1-12, 2010
116 Brunetti L, "Effects of obestatin on feeding and body weight after standard or cafeteria diet in the rat" 30 : 1323-1327, 2009
117 Nogueiras R, "Effects of obestatin on energy balance and growth hormone secretion in rodents" 148 : 21-26, 2007
118 Depoortere I, "Effect of peripheral obestatin on food intake and gastric emptying in ghrelin-knockout mice" 153 : 1550-1557, 2008
119 Zhang W, "Effect of des-acyl ghrelin on adiposity and glucose metabolism" 149 : 4710-4716, 2008
120 Lippl F, "Effect of GIP, GLP-1, insulin and gastrin on ghrelin release in the isolated rat stomach" 119 : 93-98, 2004
121 Taheri S, "Diurnal variation in orexin A immunoreactivity and prepro-orexin mRNA in the rat central nervous system" 279 : 109-112, 2000
122 Lu XY, "Diurnal rhythm of agouti-related protein and its relation to corticosterone and food intake" 143 : 3905-3915, 2002
123 Grönberg M, "Distribution of obestatin and ghrelin in human tissues: immunoreactive cells in the gastrointestinal tract, pancreas, and mammary glands" 56 : 793-801, 2008
124 Foo K, "Distribution and neuropeptide coexistence of nucleobindin-2 mRNA/nesfatin-like immunoreactivity in the rat CNS" 156 : 563-579, 2008
125 Mundinger TO, "Direct stimulation of ghrelin secretion by sympathetic nerves" 147 : 2893-2901, 2006
126 Stengel A, "Differential distribution of ghrelin-O-acyltransferase (GOAT) immunoreactive cells in the mouse and rat gastric oxyntic mucosa" 392 : 67-71, 2010
127 Pan W, "Differential BBB interactions of three ingestive peptides: obestatin, ghrelin, and adiponectin" 27 : 911-916, 2006
128 Camiña JP, "Desensitization and endocytosis mechanisms of ghrelin-activated growth hormone secretagogue receptor 1a" 145 : 930-940, 2004
129 Inhoff T, "Desacyl ghrelin inhibits the orexigenic effect of peripherally injected ghrelin in rats" 29 : 2159-2168, 2008
130 Toshinai K, "Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor" 147 : 2306-2314, 2006
131 Chen CY, "Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats" 129 : 8-25, 2005
132 Sun Y, "Deletion of ghrelin impairs neither growth nor appetite" 23 : 7973-7981, 2003
133 Tan BK, "Decreased cerebrospinal fluid/plasma ratio of the novel satiety molecule, nesfatin-1/NUCB-2, in obese humans: evidence of nesfatin-1/NUCB-2 resistance and implications for obesity treatment" 96 : E669-E673, 2011
134 Xu B, "Daily changes in hypothalamic gene expression of neuropeptide Y, galanin, proopiomelanocortin, and adipocyte leptin gene expression and secretion: effects of food restriction" 140 : 2868-2875, 1999
135 Goebel M, "Continued controversy on obestatin as a gut hormone influencing food intake and gastrointestinal motility" 4 : 143-148, 2008
136 Holst B, "Common structural basis for constitutive activity of the ghrelin receptor family" 279 : 53806-53817, 2004
137 Chartrel N, "Comment on “Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin’s effects on food intake”" 315 : 766-, 2007
138 Sakata I, "Colocalization of ghrelin O-acyltransferase and ghrelin in gastric mucosal cells" 297 : E134-E141, 2009
139 Stengel A, "Cold ambient temperature reverses abdominal surgery-induced delayed gastric emptying and decreased plasma ghrelin levels in rats" 31 : 2229-2235, 2010
140 Tschöp M, "Circulating ghrelin levels are decreased in human obesity" 50 : 707-709, 2001
141 Kamegai J, "Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats" 50 : 2438-2443, 2001
142 Zhao CM, "Characterization of obestatin- and ghrelin-producing cells in the gastrointestinal tract and pancreas of rats: an immunohistochemical and electron-microscopic study" 331 : 575-587, 2008
143 Mondal M, "Characterization of obestatin in rat and human stomach and plasma, and its lack of acute effect on feeding behavior in rodents" 198 : 339-346, 2008
144 Rindi G, "Characterisation of gastric ghrelin cells in man and other mammals: studies in adult and fetal tissues" 117 : 511-519, 2002
145 Jeon TY, "Changes in plasma ghrelin concentration immediately after gastrectomy in patients with early gastric cancer" 89 : 5392-5396, 2004
146 Kim MS, "Changes in ghrelin and ghrelin receptor expression according to feeding status" 14 : 1317-1320, 2003
147 Atsuchi K, "Centrally administered nesfatin-1 inhibits feeding behaviour and gastroduodenal motility in mice" 21 : 1008-1011, 2010
148 Seoane LM, "Central obestatin administration does not modify either spontaneous or ghrelin-induced food intake in rats" 29 : RC13-RC15, 2006
149 Goebel M, "Central nesfatin-1 reduces the nocturnal food intake in mice by reducing meal size and increasing inter-meal intervals" 32 : 36-43, 2011
150 Stengel A, "Central nesfatin-1 reduces dark-phase food intake and gastric emptying in rats: differential role of corticotropin-releasing factor2 receptor" 150 : 4911-4919, 2009
151 Schwartz MW, "Central nervous system control of food intake" 404 : 661-671, 2000
152 Annemie VD, "Central administration of obestatin fails to show inhibitory effects on food and water intake in mice" 156 : 77-82, 2009
153 Tang-Christensen M, "Central administration of ghrelin and agouti-related protein (83-132) increases food intake and decreases spontaneous locomotor activity in rats" 145 : 4645-4652, 2004
154 Barreiro ML, "Cellular location and hormonal regulation of ghrelin expression in rat testis" 67 : 1768-1776, 2002
155 Zbucki RL, "Cannabinoids enhance gastric X/A-like cells activity" 46 : 219-224, 2008
156 Ao Y, "Brainstem thyrotropin-releasing hormone regulates food intake through vagal-dependent cholinergic stimulation of ghrelin secretion" 147 : 6004-6010, 2006
157 Abizaid A, "Brain circuits regulating energy homeostasis" 149 : 3-10, 2008
158 Salome N, "Anorexigenic and electrophysiological actions of novel ghrelin receptor (GHS-R1A) antagonists in rats" 612 : 167-173, 2009
159 Moechars D, "Altered gastrointestinal and metabolic function in the GPR39-obestatin receptor-knockout mouse" 131 : 1131-1141, 2006
160 Neary NM, "Acylated ghrelin stimulates food intake in the fed and fasted states but desacylated ghrelin has no effect" 55 : 135-, 2006
161 Rodriguez A, "Acylated and desacyl ghrelin stimulate lipid accumulation in human visceral adipocytes" 33 : 541-552, 2009
162 Stengel A, "Abdominal surgery inhibits circulating acyl ghrelin and ghrelin-O-acyltransferase levels in rats: role of the somatostatin receptor subtype 2" 301 : G239-G248, 2011
163 Nakazato M, "A role for ghrelin in the central regulation of feeding" 409 : 194-198, 2001
164 Cummings DE, "A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans" 50 : 1714-1719, 2001
165 Iwakura H, "A mouse model of ghrelinoma exhibited activated growth hormone-insulin-like growth factor I axis and glucose intolerance" 297 : E802-E811, 2009