사람 태아간의 산호성 과립백혈구형성에서 산호성 과립형성에 대한 미세구조 연구 = An Ultrastructural Study on the Development of Eosinophilic Granules in Granulopoietic Cell

다국어 초록 (Multilingual Abstract)

The developmental processes of eosinophilic granule formation were ultrastructural investigation of eosinophilic granulopoiesis in 15 cases of human fetal livers from 8 to 34 weeks of gestation.
1) Numerous vesicles, microgranules and small agranular and granular vacuoles were distributed around the distended Golgi apparatus in myeloblast and eosinophilic promyelocyte.
2) Granular matrix of vacuoles contained small granular vacuoles, serveral vesicles and mutilamellar structures. The granular substance exhibited higher electron density than that of cystic rough endoplasmic reticulum(RER) and was similar partly to that of immature eosinophilic granules.
3) Distended cystic RER was fused to produce matrix of maturing granules with granular vacuoles and immature eosinophilic granules.
4) Immature eosinophilic granule which began to be produced in eosinophilic promyelocyte, had myelin sheath-like structure and debris of vesicles and granular vacuoles and those disappeared immediately. The charicteristic crystalloid inclusions began to develop in immature eosinophilic granule of myelocyte.
In summary, it is suggested that vesicles and granular vacuoles as well as RER in the myelocyte and promyelcyte are participating in the formation of immature eosinophilic granules which become mature with the appearance of charicteristic crystalloid inclusion