Magnetic Nanochain-Based Smart Drug Delivery System with Remote Tunable Drug Release by a Magnetic Field

다국어 초록 (Multilingual Abstract)

Considerable attention is given to drug delivery technology that efficiently delivers appropriate levels of drug molecules to diseased sites with significant therapeutic efficacy. Nanotechnology has been used to develop various strategies for targeted drug delivery, while controlling the release of drugs because of its many benefits. Here, a delivery system was designed to control drug release by external magnetic fields using porous silica and magnetic nanoparticles. Magnetic nanochains (MNs) of various lengths (MN-1: 1.4 ± 0.8 μm, MN-2: 2.2 ± 1.1 μm, and MN-3: 5.3 ± 2.0 μm) were synthesized by controlling the exposure time of the external magnetic force in magnetic nanoaggregates (MNCs). Mesoporous silica-coated magnetic nanochains (MSMNs) (MSMN-1, MSMN-2, and MSMN-3) were prepared by forming a porous silica layer through sol–gel polymerization. These MSMNs could load the drug doxorubicin (DOX) into the silica layer (DOX-MSMNs) and control the release behavior of the DOX through an external rotating magnetic field. Simulations and experiments were used to verify the motion and drug release behavior of the MSMNs. Furthermore, a bio-receptor (aptamer, Ap) was introduced onto the surface of the DOX-MSMNs (Ap-DOX-MSMNs) that could recognize specific cancer cells. The Ap-DOX-MSMNs demonstrated a strong therapeutic effect on cancer cells that was superior to that of the free DOX. The potent ability of these MSMNs as an external stimulus-responsive drug delivery system was proven.

참고문헌 (Reference)

1 Eunji Jang, "π-Hyaluronan nanocarriers for CD44-targeted and pH-boosted aromatic drug delivery" Royal Society of Chemistry (RSC) 1 (1): 5686-5693, 2013

2 Eun-Kyung Lim, "pH-Triggered Drug-Releasing Magnetic Nanoparticles for Cancer Therapy Guided by Molecular Imaging by MRI" Wiley 23 (23): 2436-2442, 2011

3 Chia-Hsuan Wu, "Trojan-Horse Nanotube On-Command Intracellular Drug Delivery" American Chemical Society (ACS) 12 (12): 5475-5480, 2012

4 Karel Ulbrich, "Targeted Drug Delivery with Polymers and Magnetic Nanoparticles: Covalent and Noncovalent Approaches, Release Control, and Clinical Studies" American Chemical Society (ACS) 116 (116): 5338-5431, 2016

5 구보람 ; 서혜인 ; 정봉근, "Synthesis and characterization of thermoresponsive polymeric nanoparticles" 한국바이오칩학회 8 (8): 8-14, 2014

6 Baisong Chang, "Surface functionalization of magnetic mesoporous silica nanoparticles for controlled drug release" Royal Society of Chemistry (RSC) 20 (20): 9941-9947, 2010

7 Byunghoon Kang, "Strategies for using nanoprobes to perceive and treat cancer activity: a review" Springer Science and Business Media LLC 11 (11): 13-25, 2017

8 Simona Mura, "Stimuli-responsive nanocarriers for drug delivery" Springer Science and Business Media LLC 12 (12): 991-1003, 2013

9 Wolfram C.M. Dempke, "Second- and third-generation drugs for immuno-oncology treatment—The more the better?" Elsevier BV 74 : 55-72, 2017

10 Camille Moreau Bachelard, "Risks and benefits of anticancer drugs in advanced cancer patients: A systematic review and meta-analysis" Elsevier BV 40 : 101130-101138, 2021

11 Yanru Xin, "Recent progress on nanoparticle-based drug delivery systems for cancer therapy" China Anti-cancer Association 14 (14): 228-241, 2017

12 LUMA G. MAGALHAES, "Recent Advances and Perspectives in Cancer Drug Design" FapUNIFESP (SciELO) 90 (90): 1233-1250, 2018

13 Lin, A, "Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials" 11 : 1-18, 2019

14 Yu Dang, "Nanoparticle-based drug delivery systems for cancer therapy" Elsevier BV 1 : 10-19, 2020

15 최진하 ; 이재원 ; 오병근, "Nanomaterial-Based In vitro Analytical System for Diagnosis and Therapy in Microfluidic Device" 한국바이오칩학회 10 (10): 331-345, 2016

16 윤석영 ; 장준혁 ; 권나영 ; 문석훈 ; 박영민 ; 한권훈 ; 임병권 ; 이정헌, "Multifunctional Nanomaterial-alginate Drug Delivery and Imaging System for Cancer Therapy" 한국바이오칩학회 13 (13): 236-242, 2019

17 Erdong Li, "Multifunctional Magnetic Mesoporous Silica Nanoagents for in vivo Enzyme-Responsive Drug Delivery and MR Imaging" Ivyspring International Publisher 2 (2): 233-242, 2018

18 Jaemoon Yang, "Motions of magnetic nanosphere under the magnetic field in the rectangular microchannel" Elsevier BV 317 (317): 34-40, 2007

19 Seong Deok Kong, "Magnetically Vectored Nanocapsules for Tumor Penetration and Remotely Switchable On-Demand Drug Release" American Chemical Society (ACS) 10 (10): 5088-5092, 2010

20 Yongxing Hu, "Magnetically Responsive Photonic Nanochains" Wiley 50 (50): 3747-3750, 2011

21 Shang-Hsiu, Hu, "Magnetic-sensitive silica nanospheres for controlled drug release" 24 : 239-244, 2008

22 Qirong Xiong, "Magnetic nanochain integrated microfluidic biochips" Springer Science and Business Media LLC 9 (9): 1743-1754, 2018

23 Cuilian Tao, "Magnetic mesoporous silica nanoparticles for potential delivery of chemotherapeutic drugs and hyperthermia" Royal Society of Chemistry (RSC) 43 (43): 15482-15490, 2014

24 Congying Liu, "Magnetic mesoporous silica microspheres with thermo-sensitive polymer shell for controlled drug release" Royal Society of Chemistry (RSC) 19 (19): 4764-4770, 2009

25 Joseph C. Bear, "Magnetic hyperthermia controlled drug release in the GI tract: solving the problem of detection" Springer Science and Business Media LLC 6 (6): 34271-, 2016

26 Jia Liu, "Highly Water-Dispersible Biocompatible Magnetite Particles with Low Cytotoxicity Stabilized by Citrate Groups" Wiley 48 (48): 5875-5879, 2009

27 Lixin Yang, "Fluid resistance characteristics research of nanowire rotation under a magnetic field" Springer Science and Business Media LLC 24 (24): 73-81, 2015

28 Matthew D. Norris, "Externally Induced Drug Release Systems with Magnetic Nanoparticle Carriers: An Emerging Field in Nanomedicine" Wiley 2 (2): 1800092-1800104, 2018

29 Luca Falzone, "Evolution of Cancer Pharmacological Treatments at the Turn of the Third Millennium" Frontiers Media SA 9 : 1300-1326, 2018

30 Anna Lewandowska, "Environmental risk factors for cancer – review paper" Institute of Rural Health 26 (26): 1-7, 2019

31 Peiris, P.M, "Enhanced delivery of chemotherapy to tumors using a multicomponent nanochain with radio-frequency-tunable drug release" 6 : 4157-4168, 2012

32 Michael J. Mitchell, "Engineering precision nanoparticles for drug delivery" Springer Science and Business Media LLC 20 (20): 101-124, 2020

33 Lixin Yang, "Dynamics of ferromagnetic nanowires in a rotating magnetic field" SAGE Publications 7 (7): 168781401558968-, 2015

34 Sudipta Senapati, "Controlled drug delivery vehicles for cancer treatment and their performance" Springer Science and Business Media LLC 3 (3): 7-, 2018

35 Shivakalyani Adepu, "Controlled Drug Delivery Systems: Current Status and Future Directions" MDPI AG 26 (26): 5905-5950, 2021

36 T. Helleday, "Chemotherapy-induced toxicity—a secondary effect caused by released DNA?" Elsevier BV 28 (28): 2054-2055, 2017

37 Preetha Anand, "Cancer is a Preventable Disease that Requires Major Lifestyle Changes" Springer Science and Business Media LLC 25 (25): 2097-2116, 2008

38 Jihye Choi, "Aptamer-conjugated gold nanorod for photothermal ablation of epidermal growth factor receptor-overexpressed epithelial cancer" SPIE-Intl Soc Optical Eng 19 (19): 051203-051209, 2013

39 Ya-Li Liu, "A review of magnet systems for targeted drug delivery" Elsevier BV 302 : 90-104, 2019

40 Hoare, T, "A Magnetically triggered composite membrane for on-demand drug delivery" 9 : 3651-3657, 2009