Progressive multifocal leukoencephalopathy $lt;PML) is a clinically progressive demyellinating disease of the central nervous system usually affects the immunologically compromized host. We present a case of acute lymphocytic leukemia which showed cha...
Progressive multifocal leukoencephalopathy $lt;PML) is a clinically progressive demyellinating disease of the central nervous system usually affects the immunologically compromized host. We present a case of acute lymphocytic leukemia which showed characteristic clinical course and brain computerized tomographic findings of progressive multifocal leukoencephalopathy. A 26 year-old male patient was diagnosed as acute lymphocytic leukemia. After a course of chemotherapy and prophylactic treatment of central nervous system leukemia, complete remission was achieved. Rut meningeal leukemia was developed 6 months later from the diagnosis, and he was treated with cytosine arabinoside intrathecal injections. Then he was relatively well until 19 months from the diagnosis when he became relapsed. He began to suffer from weakness and hypesthesia of the lower extremities and gaze palsy. The computerized tomogram of the brain revealed diffuse low density lesions on the central white matter which were compatible with progressive multifocal leukoencephalopathy. Delta waves and generalized slowing of the background alpha waves were noticed on electroencephalogram. Patient`s neurologic deficits progressed and he died 24 months from the diagnosis of acute lymphocytic leukemia, and 4 months from the onset of neurological symptoms.