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      KCI등재 SCIE SCOPUS

      Rapid HPLC determination of gastrodin in Gastrodiae Rhizoma

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      https://www.riss.kr/link?id=A104738930

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      다국어 초록 (Multilingual Abstract)

      Gastrodin is a major biologically active ingredient in members of the genus Gastrodia. For this reason, there are many reports on the quantification of gastrodin in Gastrodiae Rhizoma (GR) and in GR-containing herbal preparations. HPLC, HPLC–MS, and TLC are the major approaches for gastrodin quantification; however, they usually require complicated pre-treatment, lengthy analysis, and expensive instruments. Therefore, a rapid and reliable method for determining gastrodin in GR is necessary.
      Optimal HPLC separation was achieved using a Chromolith Performance RP-18e (4.8 9 100 mm, 5 lm) stationary phase. The optimal mobile phase was a mixture of water (A) and acetonitrile (B) with a gradient of 1 % B at 0–8 min, 20 % B at 8–10 min, 80–100 % B at 10–12 min, and 100 % B at 12–13 min, followed by equilibration with 1 % B for 2 min at a flow rate of 1.5 mL/min. The detection wavelength was UV220 nm. Gastrodin appeared within 4 min under the above conditions. The calibration curve of gastrodin showed good linearity in the 0.25–10.0 range (r2 = 0.9998). The limit of detection (0.13 lg), limit of quantification (0.25 lg), and reproducibilities of area and retention time (0.04 and 3.24 %, respectively) were within acceptable ranges. In addition, the intra-day precision and accuracy of gastrodin were 0.74 and 100.63 ± 0.04 %, respectively, while the inter-day precision and accuracy were 0.06 and 99.25 ± 0.05 %, respectively.
      The range of mean gastrodin content in six GR samples, which were cultivated at different sites, was 0.37–0.79 %. This result may be a guideline for the quality control of GR and GR-containing medicinal preparations.
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      Gastrodin is a major biologically active ingredient in members of the genus Gastrodia. For this reason, there are many reports on the quantification of gastrodin in Gastrodiae Rhizoma (GR) and in GR-containing herbal preparations. HPLC, HPLC–MS, and...

      Gastrodin is a major biologically active ingredient in members of the genus Gastrodia. For this reason, there are many reports on the quantification of gastrodin in Gastrodiae Rhizoma (GR) and in GR-containing herbal preparations. HPLC, HPLC–MS, and TLC are the major approaches for gastrodin quantification; however, they usually require complicated pre-treatment, lengthy analysis, and expensive instruments. Therefore, a rapid and reliable method for determining gastrodin in GR is necessary.
      Optimal HPLC separation was achieved using a Chromolith Performance RP-18e (4.8 9 100 mm, 5 lm) stationary phase. The optimal mobile phase was a mixture of water (A) and acetonitrile (B) with a gradient of 1 % B at 0–8 min, 20 % B at 8–10 min, 80–100 % B at 10–12 min, and 100 % B at 12–13 min, followed by equilibration with 1 % B for 2 min at a flow rate of 1.5 mL/min. The detection wavelength was UV220 nm. Gastrodin appeared within 4 min under the above conditions. The calibration curve of gastrodin showed good linearity in the 0.25–10.0 range (r2 = 0.9998). The limit of detection (0.13 lg), limit of quantification (0.25 lg), and reproducibilities of area and retention time (0.04 and 3.24 %, respectively) were within acceptable ranges. In addition, the intra-day precision and accuracy of gastrodin were 0.74 and 100.63 ± 0.04 %, respectively, while the inter-day precision and accuracy were 0.06 and 99.25 ± 0.05 %, respectively.
      The range of mean gastrodin content in six GR samples, which were cultivated at different sites, was 0.37–0.79 %. This result may be a guideline for the quality control of GR and GR-containing medicinal preparations.

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      참고문헌 (Reference)

      1 김규원, "꽃차용꽃의문헌을통한한의학적효능분석" 한국화훼학회 16 (16): 93-101, 2008

      2 Zhang ZC, "Two new neuroprotective phenolic compounds from Gastrodia elata" 15 : 619-623, 2013

      3 Tsai CF, "The neuroprotective effects of an extract of Gastrodia elata" 138 : 119-125, 2011

      4 Feng ZT, "Quality control of compound Jingxuanning capsules" 35 : 2171-2178, 2013

      5 Baek NI, "Isolation and identification of succinic semialdehyde dehydrogenase inhibitory compound from the rhizome of Gastrodia elata Blume" 22 : 219-224, 1999

      6 Li HX, "Identification and determination of the active compounds in Gastrodia elata Blume by HPLC" 24 (24): 579-588, 2001

      7 Li W, "HPLC-ELSD determination of gastrodin in Rhizoma Gastrodiae" 27 : 126-128, 2007

      8 Tao J, "HPLC method for identifying Gastrodia elata"

      9 Chen S, "HPLC fingerprint for the quality control of Naoshuantong capsules" 11 : 457-461, 2013

      10 Zhang L, "HPLC determination of gastrodin in Xiaoerqiying Pill" 23 : 803-804, 2013

      1 김규원, "꽃차용꽃의문헌을통한한의학적효능분석" 한국화훼학회 16 (16): 93-101, 2008

      2 Zhang ZC, "Two new neuroprotective phenolic compounds from Gastrodia elata" 15 : 619-623, 2013

      3 Tsai CF, "The neuroprotective effects of an extract of Gastrodia elata" 138 : 119-125, 2011

      4 Feng ZT, "Quality control of compound Jingxuanning capsules" 35 : 2171-2178, 2013

      5 Baek NI, "Isolation and identification of succinic semialdehyde dehydrogenase inhibitory compound from the rhizome of Gastrodia elata Blume" 22 : 219-224, 1999

      6 Li HX, "Identification and determination of the active compounds in Gastrodia elata Blume by HPLC" 24 (24): 579-588, 2001

      7 Li W, "HPLC-ELSD determination of gastrodin in Rhizoma Gastrodiae" 27 : 126-128, 2007

      8 Tao J, "HPLC method for identifying Gastrodia elata"

      9 Chen S, "HPLC fingerprint for the quality control of Naoshuantong capsules" 11 : 457-461, 2013

      10 Zhang L, "HPLC determination of gastrodin in Xiaoerqiying Pill" 23 : 803-804, 2013

      11 Shu C, "Gastrodin protects against cardiac hypertrophy and fibrosis" 359 : 9-16, 2012

      12 Wang XL, "Gastrodin prevents motor deficits and oxidative stress in the MPTP mouse model of Parkinson’s disease: involvement of ERK1/2-Nrf2 signaling pathway" 114 : 77-85, 2014

      13 Peng Z, "Gastrodin ameliorates anxiety-like behaviors and inhibits IL-1b level and p38 MAPK phosphorylation of hippocampus in the rat model of posttraumatic stress disorder" 62 : 537-545, 2013

      14 Hu Y, "Gastrodin alleviates memory deficits and reduces neuropathology in a mouse model of Alzheimer’s disease" 34 : 370-377, 2014

      15 Doo AR, "Gastrodia elata Blume alleviates L-DOPA-induced dyskinesia by normalizing FosB and ERK activation in a 6-OHDA-lesioned Parkinson’s disease mouse model" 14 : 107-114, 2014

      16 Liu Y, "Experiment study of preventive effect of gastrodin on chemotherapy drug hepatotoxicity" 25 : 587-589, 2014

      17 Deng H, "Development of HPLC method for the determination of gastrodin and parahydroxybenzyl alcohol in tall Gastrodia tuber on the polyglycol-C8 column" 34 : 615-626, 2001

      18 Ye L, "Determination of rhizoma gastrodiae by HPLC" 25 : 399-401, 2005

      19 Huang J, "Determination of gastrodin contents in wild and cultivated Gastrodia elata from different regions of Chongqing by RP-HPLC" 3 : 42-44, 2012

      20 Wang M, "Determination and thin layer identification of gastrodin content in Qiangli Dingxuan tablet" 32 : 62-64, 2012

      21 Meng G, "Application of gastrodin in prevention and treatment of osteoporosis"

      22 Li XF, "Anti-platelet aggregation function and acute toxicity of 4-hydroxy benzyl aldehyde (4-HBAL) extracted from Gastrodia elata blume" 25 : 317-320, 2013

      23 Jang YW, "Anti-asthmatic activity of phenolic compounds from the roots of Gastrodia elata Bl" 10 : 147-154, 2010

      24 Jia Y, "Analysis and pharmacokinetics studies of gastrodin and p-hydroxybenzyl alcohol in dogs using ultra-fast liquid chromatography-tandem mass spectrometry method" 99 : 83-88, 2014

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      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
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      2015-12-30 학술지명변경 한글명 : Journal of the Korean Society for Applied Biological Chemistry -> Applied Biological Chemistry
      외국어명 : Journal of the Korean Society for Applied Biological Chemistry -> Applied Biological Chemistry
      KCI등재
      2010-05-06 학술지명변경 한글명 : 한국응용생명화학회지 -> Journal of the Korean Society for Applied Biological Chemistry KCI등재
      2010-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2008-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2006-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2004-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2001-07-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      1999-01-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.81 0.21 0.61
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.49 0.43 0.422 0.06
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