뇌척수액에 대한 실험적 연구 : 제1보 지주막하 출혈액의 연령측정을 위한 면역학적 연구 Part Ⅰ Immunological Assessment of Age of Bloody Cerebrospinal Fluid = Experimental Studies on Cerebrospinal Fluid

다국어 초록 (Multilingual Abstract)

Bleeding into the subarachnoid space is one of frequent complications in neurosurgical practice and most frequently caused by rupture of meningeal vessels by trauma to the head. Hemorrhage into the subarachnoid space may occur in patient with blood dyscrasias, intracranial tumors, vascular anomalies, certain toxic or infectious diseases of the nervous system, and intracerebral hemorrhages.
It may be worthy for academic interest and clinical practice to estimate the age of blood after hemorrhage into cerebrospinal fluid (CSF). The age was estimated and assessed by an immunological method with hemoagglutination activity using native Korean phytoagglutinin.
The age of the red blood cells in RBC-CSF suspension of normal subjects was assessed and estimated by the hemoagglutination of phytoagglutinin in vitro.
Vicia PHA and Clerodendron PHA chosen from among 18 different varieties of PHA are panhemoagglutinin and demonstrated the agglutination reaction most effectively.
The agglutination activity of PHA with RBC-CSF suspension decreased gradually as time elapsed and activity subsided on 7∼8 th day.
The age of RBC in CSF can be estimated by titration.
The agglutination activity of PHA to RBC in CSF suspension continued for a longer period than that of PHA to either RBC in normal saline or anti-serum A and B in CSF.
It would be well to say that the experimental results can he applied to clinical situations, especially subarachnoid hemorrhage.