국가 흡연폐해 바이오모니터링, 2016 = National Biomonitoring Program for Exposure to Tobacco Smoke (2016-2018)

다국어 초록 (Multilingual Abstract)

This analysis performed for objective evaluation of tobacco smoke exposure, secondhand smoking exposure, setting for smoke free spots and assessment of new types of tobacco such as electronic cigarette. Urine cotinine and uine NNAL applied for the target materials of tobacco exposure and the analytical results are shown below.
A total of 3,912 urine cotinine samples were analyzed during the study period. Mean of urine cotinine measurements was 211.90±543.79 ng/mL. Internal Quality Controls (Mean ng/mL, SD ng/mL, CV %) revealed following precision in each level; G(0.58, 0.06, 10.34), J(5.68, 0.41, 7.22), K(9.45, 0.60, 6.35), M(37.78, 2.43, 6.43), N(78.58, 5.28, 6.72), O(206.33, 7.39, 3.58), P(781.25, 32.33, 4.14), Q(1859.17, 84.04, 4.52), respectively. External Quality Programs are performed on G-EQUAS and interlaboratory comparison test with split samples completed 2 times with SF General Hospital. All results are applicable.
A total of 3,131 urine NNAL samples were analyzed during the study period. Mean of urine NNAL measurements was 33.99±103.75 pg/mL except 79 samples reported as N/A. Internal Quality Controls (Mean pg/mL, SD pg/mL, CV %) revealed following precision in each level; B(2.41, 0.15, 6.22), C(4.86, 0.25, 5.11), L(10.09, 0.57, 5.63), M(47.81, 3.17, 6.64), H(201.41, 14.69, 7.30), respectively. Interlaboratory comparison test with split samples completed 2 times with SF General Hospital. All results are applicable by CLSI guidelines.

국문 초록 (Abstract)

이 연구는 국가수준의 흡연 노출 및 위해 수준의 객관적 평가, 간접흡연 노출 수준 파악과 금연 구역 설정 근거 확보하고 전자담배 등 신종 담배의 건강 위해 평가 근거 생산을 위하여 실시되었다. 현재 국내외에서 활용 가능한 흡연노출 바이오마커로는 요중 코티닌과 요중 NNAL을 분석대상으로 하였으며, 분석결과는 다음과 같다.
○ 흡연폐해 바이오모니터링
• 요중 코티닌 6,904건의 분석결과 기초 통계값은 211.90±543.79 ng/mL였고, 내부정도관리 결과(Mean ng/mL, SD ng/mL, CV %)는 각 농도별로 G(0.58, 0.06,10.34), J(5.68, 0.41, 7.22), K(9.45, 0.60, 6.35), M(37.78, 2.43, 6.43), N(78.58, 5.28,6.72), O(206.33, 7.39, 3.58), P(781.25, 32.33, 4.14), K(1859.17, 84.04, 4.52)였다. 외부정도관리 결과는 G-EQUAS 프로그램 참여 성적, SFGH와 검사실간 비교 결과모두 적합하였다.
• 요중 NNAL 3,131건의 분석결과 중 결과값이 N/A로 나온 79건을 제외한 3,057건의 기초 통계값은 33.99±103.75 pg/mL였고, 내부정도관리 결과(Mean pg/mL, SDpg/mL, CV %)는 B(2.41, 0.15, 6.22), C(4.86, 0.25, 5.11), L(10.09, 0.57, 5.63),M(47.81, 3.17, 6.64), H(201.41, 14.69, 7.30)였다. 외부정도관리는 SFGH와 검사실간비교 결과 CLSI guideline 기준에 적합하였다.