오말리주맙(Omalizumab)으로 치료한 수인성 두드러기 1예 = Aquagenic Urticaria Treated with Omalizumab

다국어 초록 (Multilingual Abstract)

Aquagenic urticaria is a rare form of physical urticaria in which a 1-2 mm wheal is produced by contact with water. Treatment options include antihistamines, ultraviolet monotherapy, topical barrier creams, and acetylcholine antagonists. Despite these pharmacologic measures, the symptoms are frequently refractory to therapy. Aquagenic urticaria lowers the patient’s quality of life and causes daily discomfort. Recently, a patient with aquagenic urticaria treated with omalizumab was reported. Here, we describe a 22-year-old man with a 3-year history of aquagenic urticaria confirmed by a water immersion test. Because he showed no improvement with antihistamines, the patient began omalizumab treatment and demonstrated an excellent response. This case provides new information for clinicians. (Korean J Med 2021;96:363-367)

참고문헌 (Reference)

1 Martínez-Escribano JA, "Treatment of aquagenic urticaria with PUVA and astemizole" 36 : 118-119, 1997

2 Chang TW, "The potential pharmacologic mechanisms of omalizumab in patients with chronic spontaneous urticaria" 135 : 337-342, 2015

3 Gallo R, "Localized salt-dependent aquagenic urticaria : a subtype of aquagenic urticaria?" 38 : 754-757, 2013

4 Juhlin L, "Familial polymorphous light eruption with aquagenic urticaria : successful treatment with PUVA" 3 : 346-349, 1986

5 Czarnetzki BM, "Evidence that water acts as a carrier for an epidermal antigen in aquagenic urticaria" 15 : 623-627, 1986

6 Mathelier-Fusade P, "Association of cold urticaria and aquagenic urticaria" 52 : 678-679, 1997

7 Shelley WB, "Aquagenic urticaria. Contact sensitivity reaction to water" 189 : 895-898, 1964

8 Kai AC, "Aquagenic urticaria in twins" 6 : 2-, 2013

9 Sibbald RG, "Aquagenic urticaria : evidence of cholinergic and histaminergic basis" 105 : 297-302, 1981

10 Rothbaum R, "Aquagenic urticaria : diagnostic and management challenges" 9 : 209-213, 2016

11 Tkach JR, "Aquagenic urticaria" 28 : 454-463, 1981

12 설정은, "Aquagenic Urticaria Diagnosed by the Water Provocation Test and the Results of Histopathologic Examination" 대한피부과학회 29 (29): 341-345, 2017

13 McGee JS, "An adolescent boy with urticaria to water : review of current treatments for aquagenic urticaria" 31 : 116-117, 2014

14 Rorie A, "A case of aquagenic urticaria successfully treated with omalizumab" 4 : 547-548, 2016

15 Ho Gyun Lee, "A case of aquagenic urticaria" 28 : 456-458, 1990