조각자(조角刺) 추출물의 항응혈 활성 = Anticoagulant Activity of Gleditsiae Spina Extract조각자(조角刺) 추출물의 항응혈 활성

다국어 초록 (Multilingual Abstract)

Objectives: This research was investigated the anticoagulant effect of the Gleditsiae spina extract. Methods: We researched prothrombin time (PT) assay, activated partial thromboplastin time (APTT) assay in vitro and in vivo using arteriovenous (A-V) shunt rat model and shortening Rat tail bleeding time (BT). A-V shunt and BT were treated with extract of Gleditsiae spina (GS) 400 ㎎/kg for a week. Results: Bleeding time of Gleditsiae spina extract in vivo had a significant increase as about 1.2 times and thrombus weight of Gleditsiae spina extract had a significant reduction of thrombus weight as 26%. Gleditsiae spina extract represented an effect of anticoagulation by operating on extrinsic pathway factor II, V, VII, X and intrinsic pathway factor Ⅷ, Ⅸ, Ⅹ, XI, XII in the coagulation system. Conclusions: Considering the above mentioned results, it is judged that a Gleditsiae Spina extract has a control effect of thrombus creation.

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