Immune recognition and evasion : molecular aspects of host-parasite interaction

목차 (Table of Contents)

• CONTENTS
• Preface = xiii
• PARTⅠ. MECHANISMS AND GENETIC CONTROL OF IMMUNE RECOGNITION
• 1. Genomic Organization of the T Cell Receptor / AGNES CHAN AND TAK W. MAK
• Introduction = 3
• Genomic Organization of the T Cell Receptor Genes = 4
• Conclusion = 12
• References = 13
• 2. Contribution of Non-B DNA Structures to Switch Recombination in Immunoglobulin Genes / JOHANNA A. GRIFFIN ; DAVID COLLIER
• Introduction = 17
• Results = 18
• Discussion = 22
• References = 27
• 3. Biological Consequences of Signal Transduction by Class Ⅱ Molecules Encoded by the Major Histocompatibility Complex Ia / JOHN C. CAMBIER ; KATHRIN R. LEHMANN
• Introduction = 29
• Results and Discussion = 30
• Conclusions = 36
• References = 36
• 4. Allelic Polymorphism of HLA Class Ⅱ Antigens: Clues to the Molecular Basis of Autoimmunity / ANIMESH A. SINHA ; HUGH O. MCDEVITT
• Introduction = 39
• MHC Class Ⅱ Structure and Function = 40
• HLA and Disease = 43
• Conclusions = 50
• References = 51
• 5. Mimicry between HLA-B27 and Bacteria: A Spurious Finding or the Link Connecting HLA-B27 and Arthritogenic Bacteria? / DWIGHT H. KONO ; JIN-HAI CHEN ; ASAO NAKAYAMA ; DAVID T.Y. YU
• Introduction = 53
• Cross-Reactivity Using Monoclonal Anti-B27 Antibodies = 54
• Evidence for Mimicry Using Synthetic Peptides = 56
• General Conclusion = 59
• References = 59
• 6. Genetic Control of Predisposition to Helminth Infection / D. WAKELIN
• Introduction = 61
• Generation of Predisposition = 63
• Analysis of Genetically Determined Predisposition = 65
• Conclusions = 72
• References = 72
• PART Ⅱ STRUCTURE OF ANTIGENIC EPITOPES: PARASITE ANTIGENS
• 7. Recognition of Protein Antigens by Antibodies: Crystal Structure of Antibody Fab Fragments Complexed with Influenza Virus Nenraminidase / W.G. LAVER ; P.M. COLMAN ; G.M. AIR ; R.G. WEBSTER ; J.N. VARGHESE ; A.T. BAKER ; P.A. TULLOCH ; W.R. TULIP
• Introduction = 78
• Structure of Fab-NA Complexes = 79
• Escape Mutants = 80
• Structure of Escape Mutants = 82
• Mechanisms of Inhibition of NA Activity by Antibody = 84
• Antibody Distortion = 85
• References = 86
• 8. Recognition of Influenza Anitgens by Class I-Restricted Cytotoxic T Lymphocytes / ALAIN TOWNSEND
• Introduction = 87
• Slightly Altered Versions of Self = 88
• How Are Cytoplasmic Antigens Recognized at the Cell Surface? = 89
• Recent Work = 89
• References = 90
• 9. The Origin of the Autoimmune Pathology Associated with Trypanosoma cruzi Infection / H. EISEN ; K. PATRY ; W. VAN VOORHIS
• Introduction = 91
• Conclusions = 101
• References = 101
• 10. Advances Toward a Vaccine against Schistosomiasis / RAYMOND J. PIERCE ; CLAUDE AURIAULT ; DENIS BOULANGER ; MONIQUE CAPRON ; DELPHINE GREZEL ; JEAN-MARIE GRZYCH ; FLORENCE VELGE-ROUSSEL ; CLAUDIE VERWAERDE ; ISABELLE ; WOLOWCZUK ; ANDRE CAPRON
• Introduction = 106
• Protective Immunity against Schistosomes = 107
• Target Antigens of Immunity = 109
• Conclusions = 119
• References = 120
• 11. Stress Proteins as Immune Targets in Bacterial and Parasitic Infections / RICHARD A. YOUNG
• Introduction = 123
• Results and Discussion = 124
• References = 128
• PART Ⅲ CYTOKINES AND HORMONES IN HOSTPARASITE INTERACTION
• 12. Autocrine-Stimulated Immortalization of Lymphocytes by the Parasite Theileria Parva / R. O. WILLIAMS ; D. A. E. DOBBELERE
• Introduction = 133
• Life Cycle = 134
• Lymphocyte Proliferation in Vitro = 136
• Growth of Theileria in Nonbovine Cells and Animals = 138
• Host-Parasite Relationship = 140
• References = 147
• 13. Characteristics, Distribution, and Possible Evolutionary Importance of the Human Growth Hormone-Like Factor from Plerocercoids of the Tapeworm Genus Spirometra / C. K. PHARES ; J. L. SHAFFER ; M. L. HEIDRICK
• Introduction = 149
• Characteristics of Growth Hormone = 150
• Characteristics of Plerocercoid Growth Factor = 150
• Possible Adaptive Roles for Plerocercoid Growth Factor = 157
• Summary and Hypothesis = 159
• References = 160
• 14. The Biochemical Basis of Cachexia of Infection / KEVIN J. TRACEY ; ANTHONY CERAMI
• Introduction = 163
• History of the Isolation of Cachectin = 164
• Catabolic Cellular Responses to Cachectin / TNF = 165
• Cachectin TNF-Induced Cachexia = 167
• Summary and Future Directions = 169
• References = 170
• PART Ⅳ GENETIC MECHANISMS IN IMMUNE EVASION: MOLECULAR GENETICS OF PARASITIC ORGANISMS
• 15. Escape from the Host Humoral Response: Examples from Two Microbial Pathogens / MAGDALENE SO ; KAREN A. NORRIS ; H. S. SEIFERT
• Text = 175
• References = 180
• 16. Multiphasic Antigenic Variation in the Bacterium that Causes Relapsing Fever / ALAN G. BARBOUR
• Introduction = 183
• Biology of Relapsing Fever = 184
• The Variable Antigens: Outer Membrance Proteins = 188
• Antigenic Variation: The Consequences of DNA Rearrangements = 190
• The vmp Genes: On Linear Plasmids = 193
• Model Mechanisms of vmp Gene Switching = 195
• References = 198
• 17. Mechanisms of Antigenic Variation in Plasmodium / THOMAS E. WELLEMS
• Imtroduction = 201
• Variations in the Tandem Repeants of Malaria Antigens = 202
• Transpositions and Rearrangements Involving Subtelomeric Regions of Chromosomes = 203
• Point Mutations and Focal Deletions = 204
• Conclusions = 205
• References = 205
• 18. Genome Structure, Transcriptional Control, and Nuclear Organization in Trypanosoma brucei / LEX H. T. VAN DER PLOEG ; DORIS B. TSE ; CATHY SHEA ; MARY GWO-SHU LEE ; JIN HUANG ; MICHAEL WEIDEN ; GLORIA RUDENKO ; KEITH GOTTESDIENER ; STEPHANIE KLCO ; STEVEN BROWN ; HUI-MIM CHUNG ; DAVID BISHOP ; ALISON RATTRAY
• The cell Surface Coat and Antigenic Variation = 208
• Chromosome Structure = 208
• DNA Recombinational Events and Differential VSG Gene Expression = 210
• Identification of Transcription Initiation Sites = 212
• Discontinuous Transcription and Trans-Splicing = 212
• α-Amanitin-Resistant Transcription of Protein-Coding Genes and Telomeres = 214
• Analysis of Nuclear Structure = 217
• Concluding Remarks = 221
• References = 222
• 19. Antigenic Variation in Giardia lamblia / THEODORE E. NASH
• Text = 225
• References = 234
• 20. Recent Developments in the Analysis of Chromosome-Sized DNA and Their Application to Studies on Giardia lamblia and Trypanosoma brucei / CASSANDRA L. SMITH
• Introduction = 237
• Principles of Pulsed-Field Gel Electrophoresis = 238
• Sizing Large DNA Molecules = 239
• Enzymatic Manipulation of Intact Chromosomes = 240
• Pulsed-Field Gel Electrophoretic Analysis of the Giardia lamblia Genome = 242
• The Large Chromosomes of Trypanosoma brucei = 242
• Prospectus = 243
• References = 243
• 21. Identification and Comparison of Putative Chlamydial Promoter Elements / JOANNE N. ENGEL ; DON GANEM
• Introduction = 245
• Results = 246
• Conclusions = 258
• References = 260
• 22. The Double-Stranded RNA Virus of Giardia lamblia / ALICE L. WANG ; ERIC S. FURFINE ; C. C. WANG
• Introduction = 262
• Results = 262
• Discussion = 267
• References = 268
• 23. Viruses and Episomes of Leishmania / K. STUART ; R. WEEKS ; C. TRIPP ; B. SMILEY ; R. ALINE, JR.
• Introduction = 269
• Methods = 270
• Results = 270
• Discussion = 277
• References = 277
• 24. gp63 as a Surface Metalloproteinase in Leishmania Virulence: Molecular Determinants of Proteolytic Activity and N-Glycosylation / K.-P. CHANG ; G. CHAUDHURI ; M. CHAUDHURI ; K. KATAKURA
• Introduction = 279
• gp63 as a Zn-Proteinase = 280
• Predicted Amino Acid Sequences at Zinc-Binding and Catalytic Sites of gp63 = 282