The First Case of Cutaneous Acanthamoebiasis Caused by Acanthamoeba triangularis in Korea

다국어 초록 (Multilingual Abstract)

A 62-year-old man with multiple myeloma visited our clinic with multiple painful erythem- atous to purpuric nodules on his whole body. He received a skin biopsy which showed septal and lobular inf lammation with vasculitis, and multiple amoebic organisms were found.
Polymerase chain reaction and culture were performed and an Acanthamoeba triangularis infection was diagnosed. This is the first report on cutaneous acanthamoebiasis caused by A.
triangularis, suggesting that A. triangularis should be regarded as a clinical pathogen that can cause ocular as well as disseminated infection.

참고문헌 (Reference)

1 Schroeder JM, "Use of subgenic 18S ribosomal DNA PCR and sequencing for genus and genotype identification of acanthamoebae from humans with keratitis and from sewage sludge" 39 : 1903-1911, 2001

2 Lee SM, "Species identification and molecular characterization of Acanthamoeba isolated from contact lens paraphernalia" 11 : 39-50, 1997

3 Johnston SP, "Resistance of Acanthamoeba cysts to disinfection in multiple contact lens solutions" 47 : 2040-2045, 2009

4 Lehmann OJ, "Polymerase chain reaction analysis of corneal epithelial and tear samples in the diagnosis of Acanthamoeba keratitis" 39 : 1261-1265, 1998

5 Visvesvara GS, "Pathogenic and opportunistic free-living amoebae : Acanthamoeba spp., Balamuthia mandrillaris, Naegleria fowleri, and Sappinia diploidea" 50 : 1-26, 2007

6 Pussard M, "Morphologie de la paroikystique et taxonomie du genre Acanthamoeba(Protozoa, Amoebida)" 8 : 557-598, 1977

7 Kong HH, "Mitochondrial DNA restriction fragment length polymorphism(RFLP)and 18S small-subunit ribosomal DNA PCR-RFLP analyses of Acanthamoeba isolated from contact lens storage cases of residents in southwestern Korea" 40 : 1199-1206, 2002

8 Ying-Hua Xuan ; 정병석 ; 홍연철 ; 공현희 ; 한태원 ; 정동일, "Keratitis by Acanthamoeba triangularis: Report of Cases and Characterization of Isolates" 대한기생충학ㆍ열대의학회 46 (46): 157-164, 2008

9 Booton GC, "Identification and distribution of Acanthamoeba species genotypes associated with nonkeratitis infections" 43 : 1689-1693, 2005

10 Yu HS, "Genetic analyses of Acanthamoeba isolates from contact lens storage cases of students in Seoul, Korea" 39 : 161-170, 2001

11 Schuster FL, "Free-living amoebae as opportunistic and non-opportunistic pathogens of humans and animals" 34 : 1001-1027, 2004

12 Kang S, "Fitzpatrick’s dermatology" McGraw-Hill 3246-3248, 2019

13 Brondfield MN, "Disseminated Acanthamoeba infection in a heart transplant recipient treated successfully with a miltefosine-containing regimen : case report and review of the literature" 19 : 10-, 2017

14 Torno MS Jr, "Cutaneous acanthamoebiasis in AIDS" 42 (42): 351-354, 2000

15 Mathers WD, "Confirmation of confocal microscopy diagnosis of Acanthamoeba keratitis using polymerase chain reaction analysis" 118 : 178-183, 2000

16 Yera H, "Comparison of PCR, microscopic examination and culture for the early diagnosis and characterization of Acanthamoeba isolates from ocular infections" 26 : 221-224, 2007

17 Slater CA, "Brief report : successful treatment of disseminated acanthamoeba infection in an immunocompromised patient" 331 : 85-87, 1994

18 Marciano-Cabral F, "Acanthamoeba spp. as agents of disease in humans" 16 : 273-307, 2003

19 Khan NA, "Acanthamoeba : biology and increasing importance in human health" 30 : 564-595, 2006

20 Booton GC, "18S ribosomal DNA typing and tracking of Acanthamoeba species isolates from corneal scrape specimens, contact lenses, lens cases, and home water supplies of Acanthamoeba keratitis patients in Hong Kong" 40 : 1621-1625, 2002