노화에 미치는 산소 유리라디칼에 관한 연구동향 = The involvement of oxygen free radicals in the onset of aging

다국어 초록 (Multilingual Abstract)

The superoxide anion radical(O₂ ­) poses a threat to macromocules and cell organelles of the living cells. This toxicity damage to all groups of proteins results in loss of enzyme function concerned with metabolism and ion transport, and peroxidation of unsaturated fatty acids and cholesterol results in a change of permeability characteristics of the membrane, and oxidative of nucleic acids results in genomic damage and thereby cause mutation, potential carcinogenesis and somatic damage that produce cellular aging.
Superoxide dismutase(SOD) has received substantial attention as a potential therapeutic agent. It has been investigated as a possible agent for the prevention of oncogenesis, the reduction of cytotoxic effect of anticancer drugs, and protection against damage in ischemic tissue. It is suggest that O₂ ­ is concerned with cellular aging, thereafter we need to investigate herb that activated to SOD.