의약품의 병용 투여 효과에 관한 연구(Ⅱ) : 마황탕 엑기스와 Aspirin 의 병용 투여가 항염 및 진통작용에 미치는 영향

다국어 초록 (Multilingual Abstract)

The extract of Galgun-tang at oral doses of 200 and 400 ㎎/㎏ showed remarkable inhibition of 42.5% and 45.0%, respectively, on the carrageenin edema in rat paw. In case of combined oral administration of the extract at each dose of 100, 200 and 400㎎/㎏ with 100㎎/㎏ of aspirin, the inhibitions were 70.5%, 83.6% and 80.7%, respectively. These results showed the remarkable effects as compared with those of aspirin which showed 50.3% and 69.4% of inhibition at doses of 100 and 200 ㎎/㎏, respectively. On the other hand, on the writhing syndrome in mice induced by 0.7% acetic acid solution, the oral administration of the extract showed remarkable inhibition of 18.5 and 47.7% at doses of 200 and 400㎎/㎏, respectively. In case of combined oral administration of the extract at each dose of 100, 200 and 400㎎/㎏ with 100㎎/㎏ of aspirin, the inhibition percentages of writhing syndromes were 66.6, 72.3 and 80.8, respectively, whereas the inhibition at doses of 100 and 200㎎/㎏ of aspirin showed 59.9 and 69.5%, respectively.