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      KCI등재 SCIE SCOPUS

      Apoptosis-Mediated Cytotoxicity of Ouabain, Digoxin and Proscillaridin A in the Estrogen Independent MDA-MB-231 Breast Cancer Cells

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      https://www.riss.kr/link?id=A104665503

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      다국어 초록 (Multilingual Abstract)

      We examined the effects of three cardiac glycosides, ouabain, digoxin and proscillaridin A, on
      the proliferation of estrogen independent MDA-MB-231 breast cancer cells. In terms of reduction
      in cell viability, the compounds rank for both 24 h and 48 h of incubation in MDA-MB-231
      cells in the order proscillaridin A > digoxin > ouabain. Digoxin for 24 h and 48 h of incubation in
      MDA-MB-231 cells proved to be only slightly more potent than ouabain, with IC50 values of 122
      ± 2 and 70 ± 2 nM, respectively, compared to 150 ± 2 and 90 ± 2 nM for ouabain. In contrast,
      proscillaridin A, was much more active and showed a high level of cytotoxic potency, IC50 51 ±
      2 and 15 ± 2 nM for 24 h and 48 h of incubation, respectively. The concentrations of digoxin,
      ouabain and proscillaridin A needed to inhibit [3H]thymidine incorporation into DNA by 50%
      (IC50) in MDA-MB-231 cells for 24 h of incubation were found to be 124 ± 2 nM, 142 ± 2 nM,
      and 48 ± 2 nM, respectively. In the present study, we demonstrated that ouabain, digoxin, and
      proscillaridin A induce apoptosis in MDA-MB-231 cells by increasing free calcium concentration
      and by activating caspase-3.
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      We examined the effects of three cardiac glycosides, ouabain, digoxin and proscillaridin A, on the proliferation of estrogen independent MDA-MB-231 breast cancer cells. In terms of reduction in cell viability, the compounds rank for both 24 h and 48 h...

      We examined the effects of three cardiac glycosides, ouabain, digoxin and proscillaridin A, on
      the proliferation of estrogen independent MDA-MB-231 breast cancer cells. In terms of reduction
      in cell viability, the compounds rank for both 24 h and 48 h of incubation in MDA-MB-231
      cells in the order proscillaridin A > digoxin > ouabain. Digoxin for 24 h and 48 h of incubation in
      MDA-MB-231 cells proved to be only slightly more potent than ouabain, with IC50 values of 122
      ± 2 and 70 ± 2 nM, respectively, compared to 150 ± 2 and 90 ± 2 nM for ouabain. In contrast,
      proscillaridin A, was much more active and showed a high level of cytotoxic potency, IC50 51 ±
      2 and 15 ± 2 nM for 24 h and 48 h of incubation, respectively. The concentrations of digoxin,
      ouabain and proscillaridin A needed to inhibit [3H]thymidine incorporation into DNA by 50%
      (IC50) in MDA-MB-231 cells for 24 h of incubation were found to be 124 ± 2 nM, 142 ± 2 nM,
      and 48 ± 2 nM, respectively. In the present study, we demonstrated that ouabain, digoxin, and
      proscillaridin A induce apoptosis in MDA-MB-231 cells by increasing free calcium concentration
      and by activating caspase-3.

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      참고문헌 (Reference)

      1 "Two hundred years of digitalis" 3-1985 9, 1986

      2 "Trease and Evan’s Pharmacognosy" London: WB Saunders 309-316, 1996

      3 "The role of calcium and cell proliferation in the pro- grammed death of androgen-independent prostatic cancer cells induced by thapsigargin" 6167-6175, 1994

      4 "The inhibition of fibroblast growth factor-2 export by cardenolides implies a novel function for the catalytic subunit of Na +, K +-ATPase" 273 : 544-551, 1998

      5 "The cooperative interaction of two diferent signaling pathways in response to bufalin induces apoptosis in human leukemia U937 cells" 271 : 14067-14073, 1996

      6 "TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB" 274 : 787-789, 1996

      7 "Sodium/potassium ATPase (Na +, K +-ATPase) and ouabain/ related cardiac glycosides: a new paradigm for development of anti-breast cancer drugs?" 96 : 1-15, 2006

      8 "Possible implication for an indirect interaction between basic fibroblast growth factor and Na +, K +-ATPase" 21 : 707-711, 1998

      9 "Physiological efects of endogenous ouabain control of intracellular Ca 2+ stores and cell responsiveness" 1993

      10 "Oleandrin suppresses activation of nuclear transcription factor-κB, activator protein-1, and c-Jun NH2- terminal kinase" 60 : 3838-3847, 2000

      1 "Two hundred years of digitalis" 3-1985 9, 1986

      2 "Trease and Evan’s Pharmacognosy" London: WB Saunders 309-316, 1996

      3 "The role of calcium and cell proliferation in the pro- grammed death of androgen-independent prostatic cancer cells induced by thapsigargin" 6167-6175, 1994

      4 "The inhibition of fibroblast growth factor-2 export by cardenolides implies a novel function for the catalytic subunit of Na +, K +-ATPase" 273 : 544-551, 1998

      5 "The cooperative interaction of two diferent signaling pathways in response to bufalin induces apoptosis in human leukemia U937 cells" 271 : 14067-14073, 1996

      6 "TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB" 274 : 787-789, 1996

      7 "Sodium/potassium ATPase (Na +, K +-ATPase) and ouabain/ related cardiac glycosides: a new paradigm for development of anti-breast cancer drugs?" 96 : 1-15, 2006

      8 "Possible implication for an indirect interaction between basic fibroblast growth factor and Na +, K +-ATPase" 21 : 707-711, 1998

      9 "Physiological efects of endogenous ouabain control of intracellular Ca 2+ stores and cell responsiveness" 1993

      10 "Oleandrin suppresses activation of nuclear transcription factor-κB, activator protein-1, and c-Jun NH2- terminal kinase" 60 : 3838-3847, 2000

      11 "Morphological and biochemical assays of apoptosis" imu (imu): 1-16, 1992

      12 "Is digitalis a therapy for breast carcinoma?" 6 : 493-496, 1999

      13 "Investi- gation of ouabain-induced anticancer effect in human androgen-independent prostate cancer PC-3 cells" 67 : 727-733, 2004

      14 "Inhibition of export of fibroblast growth factor-2 (FGF-2) from the prostate cancer cell lines PC3 and DU145 by Anvirzel and its cardiac glycoside component, oleandrin" 62 : 469-472, 2001

      15 "Inhibition of DNA topoisomerases I and II, and growth inhibition of breast cancer MCF-7 cells by ouabain, digoxin and proscillaridin A" 29 : 1493-1497, 2006

      16 "Increased gadd153 mesenger RNA level is associated with apoptosis in human leukemic cells treated with etoposide" 57 : 686-695, 1997

      17 "Fas mediated apoptosis of human jurkat T-cells: intracellular events and potentiation by redox-active alpha-lipoic acid" 6 : 481-491, 1999

      18 "Evidence of a modifying influence of heart glucosides on the development of breast cancer" 49-54, 1980

      19 "Evaluation of a tetrazolinium-based semiautomated colorimetric assay assessment of chemosensitivity testing" 936-942, 1987

      20 "Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of bcl-2 and abl" 182 : 1545-1556, 1995

      21 "Digitoxin, in non toxic concentrations, induces apoptotic cell death in Jurkat T cells in vitro" 31 : 14-20, 1999

      22 "Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients" 68 : 1642-1645, 2005

      23 "Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells" 12 : 475-483, 2001

      24 "Cleavage of structural proteins during the assembly of the head of bacteriophage T4" 680-685, 1970

      25 "Caspases and caspase inhibitors" 22 : 388-393, 1997

      26 "Cardiotonic steroids diferentially affect intracellular Na + and [Na +]i/[K +]i- independent signaling in C7-MDCK cells" 280 : 832-839, 2005

      27 "Cardiac glycosides stimulate Ca 2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells" 60 : 3807-3812, 2000

      28 "Cardiac glycosides in the next millennium" 41 : 247-254, 1999

      29 "Bumetanide annihilation of amphotericin B-induced apoptosis and cytotoxicity is due to its effect on cellular K + flux" 48 : 781-786, 2001

      30 "Bufalin reduces the level of topoisomerase II in human leukemia cells and affects the cytotoxicity of anticancer drugs" 21 : 875-883, 1997

      31 "Bufalin induces apoptosis and influences the expression of apoptosis-related genes in human leukemia cells" 19 : 549-556, 1995

      32 "Basic fibroblast growth factor levels in cancer cells and in sera of patients suffering from proliferative disorders of the prostate" 31 : 223-233, 1997

      33 "Anti-tumor activity of Digitalis purpurea subsp" 69 : 701-704, 2003

      34 "A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expresion on early apoptotic cells using fluorescein labelled annexin V" 184 : 39-51, 1995

      35 "A new generation of Ca 2+ indicators with greatly improved fluorescence properties" 3440-3450, 1985

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      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2010-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2008-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2006-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2004-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2001-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      1998-07-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 1.96 0.2 1.44
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      1.07 0.87 0.439 0.05
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