Skin and Eye Irritation of a Bioherbicide, F40362, Isolated from Trifolium repens L.

다국어 초록 (Multilingual Abstract)

The market for biopesticide is small but fast growing and large pest control companies are beginning to participate. The biopesticides replace conventional chemical pesticides in the foreseeable future. F40362 strain was selected by the screening of herbicidal activity on Trifolium repens L. and Zoysia japonica and was showed selective activity between Trifolium repens L. and Zoysia japonica. But, there is absolutely nc information on the mammalian physiology and toxicology of F40362. In view of a lack of information on its toxicity profiles, the present study performed the primary skin and eye irritation test in rabbits. F40362 was showed mild skin irritant under the conditions of this study and conjunctival redness and slight opacity on cornea appeared from 1 hour after application. The relevance of these irritation tests to evaluation of irritation in biopesticide remains to be further investigated.