측뇌실내 Desmethylimipramine의 가토혈압 하강작용 = The Hypotensive Action of Intraventricular Desmithylimipramine in Rabbits

국문 초록 (Abstract)

１）Urethane 마취 가토에서, 측뇌실내 ＤＭＩ(300㎍,1㎎)는 혈압 하강 반응을 일으켰고 정맥내 ＤＭＩ(150,500㎍/㎏)는 뚜렷한 반응을 일으키지 않았다.
２）이 ＤＭＩ의 혈압 하강 작용은, 측뇌실내 yohimb-ine, piperoxan으로 억제되었고, prazosin의 영향은 거의 받지 않았다.
３）이 ＤＭＩ의 혈압 하강 작용은 측뇌실내 clonidine-저혈압상태에서는 거의 볼수 없었고, 측뇌실내 cl-onidine의 혈압 하강작용도 ＤＭＩ-저혈압상태에서는 약화되었다.
４）Reserpine 처리가트에서는 측뇌실내 ＤＭＩ(300㎍,1㎎)는 혈압상승을 일으켰으며, 이는 측뇌실내 yohimbine의 영향은 받지 않았으나 prazosin 투여후에는 거의 나타나지 않았다.
５）측뇌실내 Norepinephrine은 측뇌실내 ＤＭＩ 300㎍ 후에는 혈압상승을 일으키지 않았으나 1㎎ 후에는 현저한 상승을 일으켰다.
６）측뇌실내 protriptyline은 혈압하강을 일으키지 않았다.
７）측뇌실내 ＤＭＩ는 가토 뇌내 α₂-adrenoceptor에 작용하여 혈압 하강을 일으키며, 이는 ＤＭＩ의 norepinephrine의 uptake 억제 효과에는 무관한 것으로 추측하였다.

다국어 초록 (Multilingual Abstract)

1) Intraventricular DMI(300㎍,1㎎) produced a hypotensive response in urethane-anesthetized rabbits, howeber Intravenous DMI produced no distinctive effect.
2) The hypotensive effect of DMI was inhibited by treating rabbits with intraventricular yohimbi-ne or piperoxan, whereas intaventricular prazosin did not affect the effect.
3) The hypotensive effect of DMI was not pro-duced in clonidine-hypotension rabbits and the hypotensive effect of olonidine was weakened in DMI-hypotension rabbits.
4) In reserpine pretreated rabbits intraventricu-lar DMI(300㎍,1㎎) produced a hypertensive respones, which was not affected by treating the rabbits with yohimbine but was inhibited by pra-zosin.
5) Intraventricular norepinephrine produced lit-tle pressor effect in the rabbits pretreated with 300㎍ of intraventricular DMI, but it produced marked pressor effect after 1㎎ of intraventricu-lar DMI.
6) Intraventricular protriptyline did not cause hypotension.
7) It is inferred that intraventricular DMI pro-duced a hypotensive response in rabbits by acting on α₂-adrenoceptor, and this was not associated with the inhibitory effect of DMI on norepineph-rine uptake in adrenergic neurons.