Colon Capsule Endoscopy: Indications, Findings, and Complications – Data from a Prospective German Colon Capsule Registry Trial (DEKOR)

다국어 초록 (Multilingual Abstract)

Background/Aims: Reliable and especially widely accepted preventive measures are crucial to further reduce the incidenceof colorectal cancer (CRC). Colon capsule endoscopy (CCE) might increase the screening numbers among patients unable orunwilling to undergo conventional colonoscopy. This registry trial aimed to document and determine the CCE indications, findings,complications, and adverse events in outpatient practices and clinics throughout Germany.
Methods: Patients undergoing CCE between 2010 and 2015 were enrolled in this prospective multicenter registry trial at six Germancenters. Patient demographics, outcomes, and complications were evaluated.
Results: A total of 161 patients were included. Of the CCE evaluations, 111 (68.9%) were considered successful. Pathological findingsin the colon (n=92, 60.1%) and in the remaining gastrointestinal tract (n=38, 24.8%) were recorded. The main finding was thepresence of polyps (n=52, 32.3%). Furthermore, five carcinomas (3.1%) were detected and histologically confirmed later. Adequatebowel cleanliness was more likely to be achieved in the outpatient setting (p<0.0001). Interestingly, 85 patients (55.6%) chose toundergo CCE based on personal motivation.
Conclusions: CCE seems to be a reliable and safe endoscopic tool for screening for CRC and detecting other diseases. Its patientacceptance and feasibility seems to be high, especially in the outpatient setting.

참고문헌 (Reference)

1 Adrián-de-Ganzo Z, "Uptake of colon capsule endoscopy vs colonoscopy for screening relatives of patients with colorectal cancer" 13 : 2293-2301, 2015

2 Hussey M, "Same-day colon capsule endoscopy is a viable means to assess unexplored colonic segments after incomplete colonoscopy in selected patients" 6 : 1556-1562, 2018

3 Farnbacher MJ, "QuickView video preview software of colon capsule endoscopy : reliability in presenting colorectal polyps as compared to normal mode reading" 49 : 339-346, 2014

4 Eliakim R, "Prospective multicenter performance evaluation of the second-generation colon capsule compared with colonoscopy" 41 : 1026-1031, 2009

5 Schoofs N, "PillCam colon capsule endoscopy compared with colonoscopy for colorectal tumor diagnosis : a prospective pilot study" 38 : 971-977, 2006

6 de Leusse A, "L’Observatoire national de l’endoscopie colique par capsule(ONECC). Présentation et bilan à deux ans" 44 : 258-261, 2014

7 Bujanda L, "Low adherence to colonoscopy in the screening of first-degree relatives of patients with colorectal cancer" 56 : 1714-1718, 2007

8 Buijs MM, "Intra and inter-observer agreement on polyp detection in colon capsule endoscopy evaluations" 6 : 1563-1568, 2018

9 Lee YJ, "Impact of reinforced education by telephone and short message service on the quality of bowel preparation : a randomized controlled study" 47 : 1018-1027, 2015

10 Christophe Saurin J, "French muticentric experience of colon capsule endoscopy in real practice : primary results of the colon capsule endoscopy observatory"ONECC"" 77 (77): AB496-AB497, 2013

11 Holme Ø, "Flexible sigmoidoscopy versus faecal occult blood testing for colorectal cancer screening in asymptomatic individuals" (9) : CD009259-, 2013

12 Shafer LA, "Factors associated with anxiety about colonoscopy : the preparation, the procedure, and the anticipated findings" 63 : 610-618, 2018

13 Alarcón-Fernández O, "Effects of colon capsule endoscopy on medical decision making in patients with incomplete colonoscopies" 11 : 534-540, 2013

14 Skinner CS, "Development of the Parkland-UT Southwestern colonoscopy reporting system(CoRS)for evidence-based colon cancer surveillance recommendations" 23 : 402-406, 2016

15 Siegel RL, "Colorectal cancer statistics, 2017" 67 : 177-193, 2017

16 Welch HG, "Colorectal cancer on the decline--why screening can’t explain it all" 374 : 1605-1607, 2016

17 Pioche M, "Colon capsule versus computed tomography colonography for colorectal cancer screening in patients with positive fecal occult blood test who refuse colonoscopy : a randomized trial" 50 : 761-769, 2018

18 Spada C, "Colon capsule versus CT colonography in patients with incomplete colonoscopy : a prospective, comparative trial" 64 : 272-281, 2015

19 Parodi A, "Colon capsule endoscopy to screen for colorectal neoplasia in those with family histories of colorectal cancer" 87 : 695-704, 2018

20 Triantafyllou K, "Colon capsule endoscopy is feasible to perform after incomplete colonoscopy and guides further workup in clinical practice" 79 : 307-316, 2014

21 Spada C, "Colon capsule endoscopy : European Society of Gastrointestinal Endoscopy(ESGE)guideline" 44 : 527-536, 2012

22 Van Gossum A, "Capsule endoscopy versus colonoscopy for the detection of polyps and cancer" 361 : 264-270, 2009

23 Groth S, "Capsule colonoscopy increases uptake of colorectal cancer screening" 12 : 80-, 2012

24 Ferlay J, "Cancer incidence and mortality worldwide : sources, methods and major patterns in GLOBOCAN 2012" 136 : E359-E386, 2015

25 Kim DH, "CT colonography versus colonoscopy for the detection of advanced neoplasia" 357 : 1403-1412, 2007

26 Kobaek-Larsen M, "Back-to-back colon capsule endoscopy and optical colonoscopy in colorectal cancer screening individuals" 20 : 479-485, 2018

27 Buijs MM, "Assessment of bowel cleansing quality in colon capsule endoscopy using machine learning : a pilot study" 6 : E1044-E1050, 2018

28 Ryerson AB, "Annual report to the nation on the status of cancer, 1975-2012, featuring the increasing incidence of liver cancer" 122 : 1312-1337, 2016

29 Rex DK, "Accuracy of capsule colonoscopy in detecting colorectal polyps in a screening population" 148 : 948-957, 2015

30 Rondonotti E, "Accuracy of capsule colonoscopy and computed tomographic colonography in individuals with positive results from the fecal occult blood test" 12 : 1303-1310, 2014

31 Leighton JA, "A grading scale to evaluate colon cleansing for the PillCam COLON capsule : a reliability study" 43 : 123-127, 2011