한라봉박으로부터 분리한 펙틴 다당의 염증성 장질환 개선효과 = Improvement effects of pectic polysaccharide isolated from the pomace of Citrus reticulata on dextran sulfate sodium-induced inflammatory bowel disease mice

다국어 초록 (Multilingual Abstract)

This study was conducted to evaluate the alleviation effects of polysaccharide fractions purified from the pomace of Citrus reticulata in a mouse model of dextran sulfate sodium (DSS)-induced inflammatory bowel disease (IBD).
Three polysaccharide fractions (CRSE-I, -II, and -III) with different molecular weights were purified from crude polysaccharide by treatment with pectinase and gel permeation chromatography using Sephadex G-100. The chemical and sugar composition results of these fractions suggested that they were pectic polysaccharides. Oral administration of CRSEI and CRSE-II recovered body weight loss and alleviated various IBD symptoms in mice. Furthermore, CRSE-I, CRSEII, and CRSE-III treatment potently suppressed several inflammatory factors in the colon tissue compared with effects in the DSS-treated group. Furthermore, CRSE-I and CRSE-II treatment recovered the production of short-chain fatty acids that was decreased by DSS administration. These results suggest that CRSE-I and CRSE-II can be used as a functional ingredient for IBD treatment.

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