Localized Drug Delivery Systems Based on Adhesive Biomaterial

다국어 초록 (Multilingual Abstract)

Marine mussel adhesion is known to be mediated by adhesive proteins, which are secreted through the mussel byssus and have great potential as biologically and environmentally friendly adhesive biomaterials due to their biocompatibility and biodegradability. In addition, mussel adhesive proteins (MAPs) have strong adhesion ability even on wet and underwater surfaces due to their unique amino acid arrangements and composition. However, researches using the natural amino acid composition have been limited due to extreme difficulties in obtaining sufficient quantities of MAPs for practical applications and commercialization. Previously, we successfully produced redesigned MAP using a bacterial expression system and this bioengineered MAP showed significant adhesion ability and biocompatibility. Herein, I will present our research team’s efforts on development and evaluations of MAP-based delivery systems for drugs including small chemicals, antibody, and stem cells.