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      Micro environment modified scaffolds for impanted of nephron progenitor cell for renal tissue regeneration = Micro environment modified scaffolds for impanted of nephron progenitor cell for renal tissue regeneration

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      https://www.riss.kr/link?id=A106265803

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      Renal diseases have been recognized as major health issues because of absence of efficient treatment and lack of organ donation. In our previous study, fibroblast-derived extracellular matrix was directly coated on three-dimensional porous PLGA scaffolds incorporated with magnesium hydroxide nanoparticles for renal regeneration. Herein, cell-derived ECM surface- modified scaffolds was more contained nephron progenitor cell (NPC) than only PLGA scaffolds. The viability and growth of NPC on the scaffolds also were improved. In vivo animal study demonstrated that the further developed scaffolds facilitate the paracrine effects of NPC and restore of renal functions.
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      Renal diseases have been recognized as major health issues because of absence of efficient treatment and lack of organ donation. In our previous study, fibroblast-derived extracellular matrix was directly coated on three-dimensional porous PLGA scaffo...

      Renal diseases have been recognized as major health issues because of absence of efficient treatment and lack of organ donation. In our previous study, fibroblast-derived extracellular matrix was directly coated on three-dimensional porous PLGA scaffolds incorporated with magnesium hydroxide nanoparticles for renal regeneration. Herein, cell-derived ECM surface- modified scaffolds was more contained nephron progenitor cell (NPC) than only PLGA scaffolds. The viability and growth of NPC on the scaffolds also were improved. In vivo animal study demonstrated that the further developed scaffolds facilitate the paracrine effects of NPC and restore of renal functions.

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