N-Dimethylnitrosamine 前處置가 四鹽化炭素에 依한 急性 肝病變에 미치는 影響에 關한 病理組織學的 硏究 = Histopathological Studies on Effects of N-DimethyInitrosamine Pretreatment upon Acute Hepatic Lesions Induced by Carbon Tetrachloride

다국어 초록 (Multilingual Abstract)

The effects of dimethylnitrosamine (one of hepatotoxin) pretreatment on carbon tetrachloride induced hepatic lesions were studied histopathologically.
The albino male rats were pretreated with 10mg, 20mg, 30mg, 40mg or 50mg per kilogram of body weight of dimethylnitrosamine (DMN), and 20 hours later 0.8ml of carbon tetrachloride (CCl_4)-- olive oil solution (1:4) per kilogram of body weight were administered intrapertioneally. As a control group, 1.0ml per kilogram of physiological solution was given to the rats and, 20 hours later 0.8ml per kilogram of CCl_4 olive oil
solution was administered.
On 1, 2, 3, 4, 5, and 6 days after CCl_4 administration, 4 animals of each group were sacrificed, and the degree of liver damage was studied histopathologically.
The results of findings are as follows:
1. The mortality in the control group was 45.8%. The lowest mortality was noted in the 10mg/kg pretreated group of dimethylnitrosamine, and the highest was in the 50mg/kg pretreated group.
2. The necrotic changes of the liver cells were mild and rapidly subsided in the 10mg/kg and 20mg/kg pretreated groups, and most severe in the 50mg/kg pretreated group of all the experimental groups.
3. The regenerative and mitotic activities of the liver cells were more active than the control group in the 10mg/kg pretreated group, and then 20mg/kg pretretreated group.
The least active and delayed changes were developed in the 50mg/kg pretreated group of all the experimental groups.
4. The regenerative activity of sinusoid-lining cells were more active and rapid than the control group in the 10mg/kg pretreated group. The 20mg/kg pretreated group was similiar too the control group, but the 40mg/kg and 50mg/kg groups show the worst activity of all the experimental groups.
5. The reorganization of the hepatic lobules were more rapidly noted than the control group in the low-dosage pretreated group (10mg/kg and 20mg/kg), but it was more delayed and worse in the high-dosage pretreated group (40mg/kg and 50mg/kg) than other groups.