만성 B 형 간염의 자연 경과중 IgM Anti - HBc 의 출연 = Spontaneous Appearance of IgM Anti - HBc in Chronic Hepatitis , Type B.만성 B 형 간염의 자연 경과중 IgM Anti - HBc 의 출연

다국어 초록 (Multilingual Abstract)

The authors report 9 patients with chronic hepatitis, type B in whom IgM anti-HBc became positive spontaneously during follow-up for 9-48 months (average 32.6 mo.). 1) Biopsy of the liver which was done in 6 revealed chronic active hepatitis with severe activity or with accompanying cirrhosis. 2) All the patients were HBeAg-positive. 3) All except one developed marked elevation of ALT when IgM anti-HBc became positive. 4) S/N ratio of IgM anti-HBc ranged from 10.3 to 20.8 (average 13,5). It persisted from 2 to 28 months and in 5 patienfs over 6 months. It is suggested that spontaneous appearance of IgM anti-HBc during the course of chronic hepatitis, type B means recurrent and active viral replication which is responsible for repeated aggravation and progression of chronic hepatitic process.