Dicarbonyl/l-xylulose reductase (DCXR) converts l-xylulose into xylitol, and reduces various α-dicarbonyl compounds, thus performing a dual role in carbohydrate metabolism and detoxification. In this study, we identified DHS-21 as the o...
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https://www.riss.kr/link?id=A107627693
Son, L.T. ; Ko, K.M. ; Cho, J.H. ; Singaravelu, G. ; Chatterjee, I. ; Choi, T.W. ; Song, H.O. ; Yu, J.R. ; Park, B.J. ; Lee, S.K. ; Ahnn, J.
2011
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SCOPUS,SCIE
학술저널
1310-1316(7쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
Dicarbonyl/l-xylulose reductase (DCXR) converts l-xylulose into xylitol, and reduces various α-dicarbonyl compounds, thus performing a dual role in carbohydrate metabolism and detoxification. In this study, we identified DHS-21 as the o...
Dicarbonyl/l-xylulose reductase (DCXR) converts l-xylulose into xylitol, and reduces various α-dicarbonyl compounds, thus performing a dual role in carbohydrate metabolism and detoxification. In this study, we identified DHS-21 as the only DCXR ortholog in Caenorhabditis elegans. The dhs-21 gene is expressed in various tissues including the intestine, gonadal sheath cells, uterine seam (utse) cells, the spermathecal-uterus (sp-ut) valve and on the plasma membrane of spermatids. Recombinant DHS-21 was shown to convert l-xylulose to xylitol using NADPH as a cofactor. Dhs-21 null mutants of C. elegans show defects in longevity, reproduction and egg-laying. Knock-down of daf-16 and elt-2 transcription factors affected dhs-21 expression. These results suggest that DHS-21 is a bona fide DCXR of C. elegans, essential for normal life span and reproduction.
Stabilization of the survival motor neuron protein by ASK1