A study was carried out using HPLC to determine the chemical stability of Augmentin^(R) oral suspension (Amoxicillin and Potassium Clavulanate) and Mephirol^(R) syrup (Sobrerol and S-Carboxylmethycysteine) mixture, stored at 2~8℃ over a period of 7d...
A study was carried out using HPLC to determine the chemical stability of Augmentin^(R) oral suspension (Amoxicillin and Potassium Clavulanate) and Mephirol^(R) syrup (Sobrerol and S-Carboxylmethycysteine) mixture, stored at 2~8℃ over a period of 7days. Augmentin^(R) suspension is reported to be stable for at least 7days in a refrigerator. Our main objective was to study its stability in Augmentin^(R) suspension and Mephirol^(R) syrup mixture. During the study period, amoxicillin component was found to be more stable than the clavulanate. But in a tendency, there were little difference between the Augementin^(R) suspension and the mixture. An increase in the pH of the samples was also observed as an increase in Mephirol^(R) syrup ratio. Despite the pH increase, no additional HPLC peaks were noted. On the basis these results, it is suggested that likewise the Augmentin^(R) suspension. Augmentin^(R) suspension and Mephirol^(R) syrup mixture is stable for 7days in a refrigerator.