식도의 전암성 병변과 암종에서 p53단백 발현에 관한 면역조직화학적 연구 = Immunohistochemical Expression of p53 in Esophageal Dysplasia and Carcinomas

다국어 초록 (Multilingual Abstract)

The immunohistochemical expression of p53 protein was evaluated in formalin fixed, paraffin embedded surgical specimens from 27 patients with esophageal carcinoma.
We tested p53 expression in 17 samples of low grade and 24 samples of high grade esophageal dysplasia(ED) coexisting with esophageal cancer(ESC) in 27 patients who underwent partial or total esophagectomy.
In the normal mucosa, a positive immunoreaction was detected in 8 of 27 cases, always restricted to the lower half of the esophageal mucosa thickness.
We detected p53 positive nuclei in 10 of 17, 17 of 24, and 21 of 27 samples of low grade ED, high-grade ED, and ESC, respectively.
Cases exhibiting positive nuclear staining in dysplastic samples also demonstrated positive immunoreaction in the carcinomatous tissue.
Immunoreactivity in cancer cells was never found in the absence of positive dysplastic nuclei.
A significantly higher score of p53 positive nuclei was detected in high grade dysplasia versus low grade dysplasia, and in low grade dysplastic lesions compared with normal mucosa.
These results sugggest that p53 mutation may represent an early event in eso phageal oncogenesis.