위해성평가의 불확실도 분석과 활용방안 고찰 = Uncertainty Analysis and Application to Risk Assessment

다국어 초록 (Multilingual Abstract)

Objectives: Risk assessment is a tool for predicting and reducing uncertainty related to the effects of future activities. Probability approaches are the main elements in risk assessment, but confusion about the interpretation and use of assessment factors often undermines the message of the analyses. The aim of this study is to provide a guideline for systematic reduction plans regarding uncertainty in risk assessment. Methods: Articles and reports were collected online using the key words "uncertainty analysis" on risk assessment. Uncertainty analysis was conducted based on reports focusing on procedures for analysis methods by the World Health Organization (WHO) and U.S. Environmental Protection Agency (USEPA). In addition, case studies were performed in order to verify suggested methods qualitatively and quantitatively with exposure data, including measured data on toluene and styrene in residential spaces and multi-use facilities. Results: Based on an analysis of the data on uncertainty, three major factors including scenario, model, and parameters were identified as the main sources of uncertainty, and tiered approaches were determined. In the case study, the risk of toluene and styrene was evaluated and the most influential factors were also determined. Five reduction plans were presented: providing standard guidelines, using reliable exposure factors, possessing quality controls for analysis and scientific expertise, and introducing a peer review system. Conclusion: In this study, we established a method for reducing uncertainty by taking into account the major factors. Also, we showed a method for uncertainty analysis with tiered approaches. However, uncertainties are difficult to define because they are generated by many factors. Therefore, further studies are needed for the development of technical guidelines based on the representative scenario, model, and parameters developed in this study.

참고문헌 (Reference)

1 김윤신, "신축공동주택내 실내유해공기오염물질(HAPs)의 건강위해성평가" 한국환경보건학회 33 (33): 1-10, 2007

2 Bennett DH, "n uncertainty in redediation analysis: variance propagation from subsurface transport to exposure modeling" 62 : 117-129, 1998

3 Committee on toxicity of chemicals in food, consumer products and the environment., "Variability and uncertainty in toxicology of chemicals in food, consumer products and the environment" 61-65, 2007

4 Kalberlah F, "Uncertainty in toxicological risk assessement for non-carcinogenic health effects" 37 : 92-104, 2003

5 World Health Organization. International programme on chemical safety, "Uncertainty and data quality in exposure assessment, Part 1: Guidance document on characterizing and communicating uncertainty in exposure assessment" 15-66, 2008

6 US Environmental Protection Agency, "Toxicological review of toluene(CAS No. 108-88-3)"

7 Agency for Toxic Substances and Disease Registry, "Toxicological profile for styrene"

8 Aven T, "Some considerations on the treatment of uncertainties in risk assessment for practical decision making" 96 : 64-74, 2011

9 Liu ZQ, "Sensitivity of key factors and uncertainties in health risk assessment of benzene pollutant" 19 : 1272-1280, 2007

10 Liu ZQ, "Sensitivity of key factors and uncertainties in health risk assessment of benzene pollutant" 19 : 1272-1280, 2007

11 Moschandreas DJ, "Scenario-modelparameter:a new method of cumulative risk uncertainty analysis" 28 : 247-261, 2002

12 National Research Council, "Risk assessment in the Federal Government: Managing the process" National Academy 1983

13 US Environmental Protection Agency, "Risk assessment guidance for superfund: volume III - part A, process for conducting probabilistic risk assessment"

14 US Environmental Protection Agency, "Risk assessment guidance for superfund volume I Human health evaluation mannual(Part A)" 2-40, 1989

15 Sassi G, "Quantitative estimation of uncertainty in human risk analysis" 145 : 296-304, 2007

16 Frey HC, "Quantitative analysis of uncertainty and variability in environmental policy making"

17 Apeland A, "Quantifying uncertainty under a predictive, epistemic approach to risk analysis" 75 : 93-102, 2002

18 Joo YS., "Probabilistic risk assessment" Korea Food & Drug Administration press 28-39, 2013

19 Food and Agriculture Organization of the United Nations and World Health Organization, "Principles and methods for the risk assessment of chemicals in food. Environmental Health Criteria 240"

20 US Environmental Protection Agency, "Policy for use of probabilistic analysis in risk assessment"

21 Lee JH, "Multi-media and multi pathway aggregate risk assessment(IV): Lean, Arsenic, and Cadmium" National Institute of Environmental Research Press 2014

22 Choi KH, "Multi-media and multi pathway aggregate risk assessment(III): Bisphenol A and Polybrominated diphenyl ethers" National Institute of Environmental Research Press 2013

23 Lee JH, "Multi-media and multi pathway aggregate risk assessment(II): Di(2-ethylhexyl)phthalate and Formaldehyde" National Institute of Environmental Research Press 2012

24 Lee JH, "Multi-media and multi pathway aggregate risk assessment(I): Toluene" National Institute of Environmental Research Press 2011

25 Roy, W.W., "Methodology for chracterization of uncertainty in exposure assessments" US Environmental Protection Agency 1985

26 Jang JY, "Korean exposure factors handbook" Ministry of Environment Press 2007

27 World Health Organization, "International Agency for Research on Cancer"

28 US Environmental Protection Agency, "Integrated risk information system"

29 US Environmental Protection Agency, "Human health risk assessment protocol" US Environmental Protection Agency press 1-8, 2005

30 US Environmental Protection Agency, "Human health evaluation manual, supplemental guidance:Standard default exposure factors" 1991

31 "Human exposure assessment, Environmental health criteria 214" World Health Organization 2000

32 "Guidelines for risk assessment"

33 US Environmental Protection Agency, "Guidelines for exposure assessment" 90-98, 1992

34 European Food Safety Authority, "Guidance of the scientific committee on a request from EFSA related to uncertainties in dietary exposure assessment"

35 "Guidance for human exposure assessement"

36 US Environmental Protection Agency, "Exposure factors handbook"

37 Gallagher SS, "Cumulative risk assessment lessons learned: A review of case studies and issue papers" 120 : 697-705, 2015

38 Kim YS, "A study on public and small-scale facilities unregulated by Korean air act (I)" Ministry of Environement Press 197-201, 2006

39 Kwon MH, "A study on management of major indoor air pollutants by house type in Korea(I):Indoor air pollution and health effects in residential apartment" National Institute of Environmental Research Press 60-62, 2009