발생과정에서 연골형성의 조절과 이의 연골조직공학에의 응용 = Feature Article : Control of the Chondrogenesis during the Development and its Application for Cartilage Tissue Engineering

국문 초록 (Abstract)

연골은 중배엽성 기원의 조직으로서 성체에서 관절의 윤활 및 충격흡수기능을 담당한다. 관절연골은 손상 후 잘 재생이 되지 않으므로 조직공학적인 방법을 통하여 연골의 재생을 시도하려는 연구가 많이 진행되고 있다. 발생과정에서 연골이 생성되는 과정을 잘 이해한다면, 즉 연골분화과정을 조절하는 외인성 요인(환경적)및 내재성 요인(유전적 조절)에 관한 정확한 기전을 안다면 이를 연골조직공학에 적용하여 보다 성공적인 인공연골을 개발할 수 있을 것이다. 본고에서는 발생과정중의 연골분화과정 중에 발생하는 형태유전적인 변화 및 조절기작과 연골의 전사조절인자 및 연관된 유전자의 역할, 간엽 응축 및 연골의 성숙에 있어 세포외기질의 역할을 정리하고 발생과정의 연골분화를 모방할 것으로 추정되는 성체연골모전구세포에 대한 최신 지견을 요약하며 또한 연골재생에 최근에 적용되고 있는 새로운 생체재료들과 그 적용에 대해서 논의하고자 한다.

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