Two cases of metastatic calcinosis cutis = Two cases of metastatic calcinosis cutis

다국어 초록 (Multilingual Abstract)

Calcinosis cutis (CC) represents the deposition of calcium in the skin. CC can be divided into four categories; dystrophic, metastatic, idiopathic and iatrogenic CCs. Dystrophic CC occurs on damaged tissue by various underlying conditions with normal serum level of calcium (Ca) and phosphate (P). Idiopathic CC is not related to any tissue defects or metabolic abnormalities of Ca and P. Iatrogenic CC occurs secondarily by medical procedures such as intravenous administration of Ca or P. Lastly, metastatic CC is related to abnormalities of Ca and P metabolism, and generally associated with hyperphosphatemia and hypercalcemia. Metastatic CC is most commonly associated with chronic renal failure (CRF). We present two cases of metastatic CC. Both patients had underlying CRF with hemodialysis. The first patient was 64-year-old woman having multiple yellowish nodules on her hands which was initially confused with the non-tuberculous mycobacterium (NTM) infection. The second patient, a 53-year-old man, developed a rigid nodule on his finger. The skin specimens presented calcium deposits in the dermis and both of them showed significantly elevated serum P levels. We therefore diagnosed these two cases as metastatic calcinosis cutis.