動物硬組織抽出物에 依한 麻藥中毒解毒性에 關한 硏究 : 第一報 : 窄山甲 및 家畜의 角 및 蹄(牛角, 牛蹄, 馬蹄, 豚蹄)에서 分離한 Keratin의 麻藥中毒患者 習慣性治療에 對한 特效性에 關하여 (Ⅰ) Studies on the curing effect of Keratins from Squama manitis, and from domestic animal's horns and hoofs on narcotic addiction. = Studies on the animal hard tissue extract as an agent against narcotism

다국어 초록 (Multilingual Abstract)

One of Korean folk medicine consisted with eight oriental crude drugs, Panax Ginseng Radix alba, Rehmannia glutinosa Liboschitz var. purpurea Makino, Cyperus rotundus L., Angelica gigas Nakai, Anisomeles indica O. Kunze, Strychnos Ignatii Bergius, Glycyrrhiza glabra L. var. glandulifera Regel et herder, and Squama Manitis(the back of Manis pentadactyla L.) has been known to have some effectiveness against narcotism.
From a series of systematic clinical investigation, it was noticed that antinarcotic activity is originated in Squama Manitis and rest of seven drugs do not show any significant effect upon removing abstinence symptom.
In other to pursue an active ingredient and to increase its potency in Squama Manitis, it was ground to 200 mesh powder and extracted with 95% ethanol. The 95% ethanol a insoluble residue was extracted repeatedly with 70% ethanol at room temperature.
The 70% ethanol insoluble residue was then extracted repeatedly with large excess amount of hot water(80―90℃). The combined hot water extract (50 times of original powder volume) was reduced its volume about one hundredth on the water bath.
The precipitate which was produced by condensing the extract was separated, washed with 70% ethanol, 95% ethanol, ethyl ether, and dried over phosphorus