혈우병 환자에서 발생한 혈변으로 진단된 크론병 2예 = CASE REPORT : Two Cases of Crohn`s Disease Presented with Hematochezia in Patients with Hemophilia

다국어 초록 (Multilingual Abstract)

The etiology of Crohn`s disease, which is a chronic inflammatory condition that potentially involves any location of the alimentary tract from the mouth to the anus, is unknown. However, there is strong evidence that vascular damage could play a role in the pathogenesis of Crohn`s disease. Crohn`s disease is mediated by multifocal gastrointestinal infarctions, which occur at an early stage in the disease process. Persistent activation of coagulation in patients with Crohn`s disease has been shown. In contrast, hemophilia is an inherited disorder of coagulation. The deficiencies of clotting factors usually involve occult or overt bleeding. The pathogenic mechanisms of Crohn`s disease and hemophilia are incompatible. An association between Crohn`s disease and hemophilia has not been reported in Korea. We managed 21- and 33-year-old men with Crohn`s disease associated with hemophilia, who presented with hematochezia. (Intest Res 2011;9:9-39)

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