소아에서 발생한 미만성 범세기관지염 1례 = A Case of Diffuse Panbronchiolitis Developing in Childhood

국문 초록 (Abstract)

미만성 범세기관지염은 호흡세기관지의 전층을 침범하는 진행성의 만성 염증성 폐질환으로 주로 40대 이후에 증상이 나타나며, 소아에서는 매우 드문 것으로 되어 있다. 저자들은 수년간의 만성적인 기침과 가래를 주소로 내원한 12세 여아에서 폐결핵으로 치료하였으나 방사선 검사상 호전이 없어, 임상 경과와 고해상도 전산화 단층 검사, 폐기능 검사 및 기관지 조직 검사 등을 통하여 미만성 범세기관지염으로 진단할 수 있었던 증례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. 소아에서도 만성 기침과 부비동염의 병력이 있는 환자에서 흉부방사선 검사상 폐결핵이 의심될 때 미만성 범세기관지염도 감별해야 될 질환의 하나로 포함시켜야 할 것으로 생각된다.

다국어 초록 (Multilingual Abstract)

Diffuse panbronchiolitis(DPB) is a chronic inflammatory airway disease predominantly affecting respiratory bronchioles, with distinct clinicopathological profiles. It was first described in 1966 by Yamanaka et al. The etiology of DPB is not yet clear, and the natural history of the disease is respiratory failure leading to cor pulmonale and ultimately death. But the long-term use of low-dose macrolide has proven to be highly effective in treating patients with DPB. Usual age at diagnosis is over 40. A few cases of DPB have been reported in Korea since 1992 but there have been no reports in children. We experienced a case of DPB in a 12-year-old girl. Therefore, we report the case with a brief review of the related literature

참고문헌 (Reference)

1 "clinical significance of high- resolution CT and radioaerosol scan manifestations" 144 : 124-35, tubercrespirdis1997

2 "Tumor necrosis factor alpha and interleukin 8 in bronchoalveolar lavage fluid of patients with diffuse panbronchiolitis a potential mechanism of macrolide therapy" 63 : 42-8, 1996

3 "Reversible airway lesions in diffuse panbronchiolitis" 107 : 120-5, 1995

4 "Neutrophil chemotactic activity in bronchoalveolar lavage fluid recovered from patients with diffuse panbronchiolitis" 43 : 279-87, 1996

5 "Long-term efficacy and safety of clarithromycin treatment in patients with diffuse panbronchiolitis" 97 : 844-50, 2003

6 "Long term effect of erythromycin therapy in patients with chronic Pseudomonas aeruginosa infection" 50 : 1246-52, 1995

7 "Diffuse panbronchiolitis:chest radiograph and HRCT finding in 8 patients" 28 : 553-7, 1992

8 "Diffuse panbronchiolitis:a disease of the transitional zone of the lung" 83 : 63-9, 1983

9 "Diffuse panbronchiolitis:Evaluation with high-resolution CT" 168 : 433-8, 1988

10 "Diffuse panbronchiolitis--a thin-section CT scoring system" 43 : 63-71, 1996

11 "Diffuse panbronchiolitis" 44 : 964-74, 1997

12 "Bronchiectasis in diffuse panbronchiolitis:high resolution CT assessment" 30 : 1039-44, 1994

13 "Analysis of HLA antigens in patients with diffuse panbronchiolitis" 141 : 1459-62, 1990