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      KCI등재 SCOPUS

      Effect of Heat Shock Protein 72 Expression on Etoposide-induced Cell Death of Rat Retinal Ganglion Cells

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      https://www.riss.kr/link?id=A103854048

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      다국어 초록 (Multilingual Abstract)

      Purpose: To assess whether the expression of heat shock protein 72 (Hsp72) protects rat retinal ganglion cells (RGC-5) from apoptotic cell death.
      Methods: Hsp72 expression in RGC-5 cells transduced with replication-deficient recombinant adenovirus was analyzed by Western blot analysis and immunofluorescence. The effect of Hsp72 expression on etoposide-induced apoptotic cell death was examined by microscopic analysis and confirmed by cell proliferation assay.
      Results: Western blot analysis and immunofluorescence clearly showed adenovirus-mediated Hsp72 expression in RGC-5 cells. Treatment with etoposide resulted in the death of a proportion of the cells by apoptosis. However, this apoptotic cell death was significantly reduced in cells expressing Hsp72, with the reduction in cell death correlating to the level of Hsp72 expression.
      Conclusions: Over-expression of Hsp72 alone is sufficient to rescue neuronal cells from apoptotic cell death, suggesting that fine-tuning its expression may be an effective neuroprotective approach in retinal degenerative disease
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      Purpose: To assess whether the expression of heat shock protein 72 (Hsp72) protects rat retinal ganglion cells (RGC-5) from apoptotic cell death. Methods: Hsp72 expression in RGC-5 cells transduced with replication-deficient recombinant adenovirus was...

      Purpose: To assess whether the expression of heat shock protein 72 (Hsp72) protects rat retinal ganglion cells (RGC-5) from apoptotic cell death.
      Methods: Hsp72 expression in RGC-5 cells transduced with replication-deficient recombinant adenovirus was analyzed by Western blot analysis and immunofluorescence. The effect of Hsp72 expression on etoposide-induced apoptotic cell death was examined by microscopic analysis and confirmed by cell proliferation assay.
      Results: Western blot analysis and immunofluorescence clearly showed adenovirus-mediated Hsp72 expression in RGC-5 cells. Treatment with etoposide resulted in the death of a proportion of the cells by apoptosis. However, this apoptotic cell death was significantly reduced in cells expressing Hsp72, with the reduction in cell death correlating to the level of Hsp72 expression.
      Conclusions: Over-expression of Hsp72 alone is sufficient to rescue neuronal cells from apoptotic cell death, suggesting that fine-tuning its expression may be an effective neuroprotective approach in retinal degenerative disease

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      참고문헌 (Reference)

      1 Beere HM., "“The stress of dying”: the role of heat shock proteins in the regulation of apoptosis" 117 (117): 2641-2651, 2004

      2 Guzhova I, "vitro studies show that Hsp70 can be released by glia and that exogenous Hsp70 can enhance neuronal stress tolerance" 914 : 66-73, 2001

      3 Yenari MA, "The neuroprotective potential of heat shock protein 70 (HSP70)" 5 : 525-531, 1999

      4 Shieds MB, "Textbook of glaucoma. 4th ed" Williams & Wilkins 153-176, 1998

      5 Srivastava P., "Roles of heat-shock proteins in innate and adaptive immunity" 2 : 185-194, 2002

      6 Ishii Y, "Retinal ganglion cell protection with geranylgeranylacetone, a heat shock protein inducer, in a rat glaucoma model" 44 : 1982-1992, 2003

      7 Van Bergen NJ, "Recharacterization of the RGC-5 retinal ganglion cell line" 50 : 4267-4272, 2009

      8 Mizumoto K, "Programmed cell death (apoptosis) of mouse fibroblasts is induced by the topoisomerase II inhibitor etoposide" 46 : 890-895, 1994

      9 Amin V, "Over-expression of heat shock protein 70 protects neuronal cells against both thermal and ischaemic stress but with different efficiencies" 206 : 45-48, 1996

      10 Quigley HA, "Number of people with glaucoma worldwide" 80 : 389-393, 1996

      1 Beere HM., "“The stress of dying”: the role of heat shock proteins in the regulation of apoptosis" 117 (117): 2641-2651, 2004

      2 Guzhova I, "vitro studies show that Hsp70 can be released by glia and that exogenous Hsp70 can enhance neuronal stress tolerance" 914 : 66-73, 2001

      3 Yenari MA, "The neuroprotective potential of heat shock protein 70 (HSP70)" 5 : 525-531, 1999

      4 Shieds MB, "Textbook of glaucoma. 4th ed" Williams & Wilkins 153-176, 1998

      5 Srivastava P., "Roles of heat-shock proteins in innate and adaptive immunity" 2 : 185-194, 2002

      6 Ishii Y, "Retinal ganglion cell protection with geranylgeranylacetone, a heat shock protein inducer, in a rat glaucoma model" 44 : 1982-1992, 2003

      7 Van Bergen NJ, "Recharacterization of the RGC-5 retinal ganglion cell line" 50 : 4267-4272, 2009

      8 Mizumoto K, "Programmed cell death (apoptosis) of mouse fibroblasts is induced by the topoisomerase II inhibitor etoposide" 46 : 890-895, 1994

      9 Amin V, "Over-expression of heat shock protein 70 protects neuronal cells against both thermal and ischaemic stress but with different efficiencies" 206 : 45-48, 1996

      10 Quigley HA, "Number of people with glaucoma worldwide" 80 : 389-393, 1996

      11 Park KH, "Induction of heat shock protein 72 protects retinal ganglion cells in a rat glaucoma model" 42 : 1522-1530, 2001

      12 Barbe MF, "Hyperthermia protects against light damage in the rat retina" 241 : 1817-1820, 1988

      13 Tezel G, "Heat shock proteins, immunity and glaucoma" 62 : 473-480, 2004

      14 Kiang JG, "Heat shock protein 70 kDa: molecular biology, biochemistry, and physiology" 80 : 183-201, 1998

      15 Rordorf G, "Heat shock protects cultured neurons from glutamate toxicity" 7 : 1043-1051, 1991

      16 Asea A, "HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine" 6 : 435-442, 2000

      17 Martin KR, "Gene delivery to the eye using adeno-associated viral vectors" 28 : 267-275, 2002

      18 Calderwood SK, "Extracellular heat shock proteins in cell signaling and immunity" 1113 : 28-39, 2007

      19 Shieds MB, "Classification of the glaucoma, In The glaucomas. 2nd ed" Mosby 717-725, 1996

      20 Tavaria M, "A hitchhiker’s guide to the human Hsp70 family" 1 : 23-28, 1996

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2024 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2021-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2020-01-01 평가 등재학술지 선정 (재인증) KCI등재
      2019-12-01 평가 등재후보로 하락 (계속평가) KCI등재후보
      2010-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2009-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2007-01-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.11 0.11 0.12
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.1 0.13 0.482 0.03
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