생약의 β-Glucuronidase 저해와 간장보호효과 = β-Glucuronidase-inhibitory Activity and Hepatoprotective Effect of Herbal Medicines

다국어 초록 (Multilingual Abstract)

Inhibitory effect of water and ethyl acetate extract of 60 kinds of herbal medicines was investigated on β-glucuronidase. Among water extract of them, Galla Rhois had the most potent β-glucuronidase-inhibitory activity. Termaliae Fructus, Amomi Tsa-ko Fructus and Arecae Semen were also potent inhibitors. Among ethyl acetate extract of them, Galla Bhois had the most potent β-glu-curonidase-inhibitory activity. Nelumbinis Semen. Ephedrae Radix and Termaliae Fructus were also potent inhibitors. The extract of Galla Rhois had potent hepa-toprotective effect on CCl₄-induced hepatotoxicity of rats. These results suggest that the β-glucuronidase seems to be closely related to the liver injury, which could be prevented by the inhibitor of β-glucuronidase.