右歸飮 八味地黃湯 煎湯液 投與가 家兎 腎臟機能 및 血漿 Aldosterone 濃度에 미치는 影響 = Effects of Wookwiyeum(右歸飮) and Palmijihwangtang(八味地黃湯) Water Extract on the Renal Function and Plasma Aldosterone Concentration in Rabbits

다국어 초록 (Multilingual Abstract)

Shen-Yang(腎陽) is the energy or motivating force for the physiological function of kidney as well as the source of life processes. Shen-Yang plays an important role in the body flued regulation in Oriental Medicine. Insufficiency of Shin-Yang has been claimed to cause frequent micturition or oligurea, and edema.
Wookwiyeum(WKY) and Palmijihwnagtang(PJT) have been applied for the treatment of impairment of Shen-Yang and recently of chronic nephritis, diabetes insipidus and hypertension etc.
This study was carried out to evaluate the effects of WKY and PJT on the renal function and levels of plasma aldosterone in rabbits.
The results obtained were as follows:
1. Intravenous administration of 0.3㎖/kg of WKY water extract in the unanesthetized rabbit caused significant increase in urine volum, glomerular filtration rate, free water clearance and urinary excretion of potassium.
2. After intravenous administration of 0.6㎖/kg of WKY water extract in the unanesthetized rabbit, urine volume, glomerular filtration rate and urinary excretion of electrolytes were increased significantly, but free water clearance didn't show significance.
3. Intravenous administration of 0.3㎖/kg, of PJT water extract in the unanesthetized rabbit caused effective increase in urine volume, renal plasma flow, glomerular filtration rate, free water clearance and urinary excretion of potassium and chloride.
4. After intravenous administration of 0.6㎖/kg of PJT water extract in the unanesthetized rabbit, urine volume were decreased without significance, and renal plasma flow and free water clearance were decreased significantly, but glomerular filtration rate and urinary excretion of sodium and chloride were increased significantly.
5. The levels of plasma aldosterone were decreased remarkably after intravenous administration of WKY and also PJT in hydrated rabbits.
6. Mean arterial blood pressure showed significant increase after administration of 0.3㎖/kg of WKY water extract, but decreased remarkably after administration of 0.6㎖/kg of WKY water extract and PJT water extract.
These results suggest that WKY and PJT water extract have diuretic and antihypertensive effect which may be caused by renal hemodynamic and hormonal change, and by decrease in peripheral vascular resistance.