RISS 검색 - 국내학술지논문 상세보기

다국어 초록 (Multilingual Abstract)

Background: Korean Red Ginseng (KRG) is widely used for strengthening the immune system andfighting fatigue, especially in people with deficiency syndrome. However, there is concern that the longtermapplication or a high dose of KRG can cause “fireness” (上火in Chinese) because of its “dryness” (燥性in Chinese). The aim of this study was to assess the safety and efficacy of a 4-week treatment with KRGin participants with deficiency syndrome.
Methods: This was a 4-week, randomized, double-blind, placebo-controlled clinical trial. A total of 180Chinese participants were randomly allocated to three groups: placebo control group, participants weregiven a placebo, 3.6 g/d; KRG 1.8 g and 3.6 g groups. The primary outcomes were the changes in firenessand safety evaluation (adverse events, laboratory tests, and electrocardiogram). The secondary outcomeswere the efficacy of KRG on fatigue, which include the following: traditional Chinese medicine (TCM)symptom scale and fatigue self-assessment scale.
Results: Of the 180 patients, 174 completed the full study. After 4 weeks of KRG treatment, the Fire-heatsymptoms score including Excess fire-heat score and Deficient fire-heat score showed no significantchange as compared with placebo treatment, and no clinically significant changes in any safetyparameter were observed. Based on the TCM syndrome score and fatigue self-assessment score, TCMsymptoms and fatigue were greatly improved after treatment with KRG, which showed a dose- and timedependenteffect. The total effective rate was also significantly increased in the KRG groups.
Conclusion: Our study revealed that KRG has a potent antifatigue effect without significant adverse effectsin people with deficiency syndrome. Although a larger sample size and longer treatment may berequired for a more definite conclusion, this clinical trial is the first to disprove the common conceptionof “fireness” related to KRG.

참고문헌 (Reference)

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