다른 강도의 유산소성 및 저항성 운동이 제2형 당뇨 마우스의 항당뇨, 지질 개선에 미치는 영향 = Effects of Different Intensity Aerobic and Resistance Exercise on Anti-diabetic and Lipid Profile Improvement in Type 2 Diabetic mice

다국어 초록 (Multilingual Abstract)

The purpose of this study was to examine the effects of aerobic and resistance exercise of different intensity on anti-diabetic and lipid profile improvement in type 2 diabetic mice. C57BL/6 mice were divided into six groups (n=8, in each group): normal group (Normal), type 2 diabetes (DM), type 2 diabetes+VO 2 max 50% aerobic exercise group (DM50A), type 2 diabetes+VO 2 max 75% aerobic exercise group (DM75A), type 2 diabetes+1RM 50% resistance exercise group (DM50R), and type 2 diabetes+1RM 75% resistance group (DM75R). DM50A and DM75A were subjected to treadmill exercise 40 min/day, 5 days/week, during 8 weeks (DM50A, at the speed of 8 m/min for 1-4 weeks and 8~10 m/min for 5-8 weeks; DM75A, 12 m/min for 1-4 weeks and 12~14 m/min for 5-8weeks). DM50R (1RM50%) and DM75R (1RM75%) were subjected to ladder-climbing exercise with weights secured to their tails, 8 set/day, 5 days/week, during 8 weeks. After 8 weeks of exercise, fasting blood glucose and HOMA-IR was significantly lower in DM group than in DM group. HbA1c showed significantly lower DM50R and DM75R groups than DM group. HDL-C showed the highest level in DM75A group and triglyceride was lowest in DM75R group. The cardiovascular risk index was lowest in the Normal and DM75A groups. Therefore, moderate intensity exercise in T2DM mice showed better improvement in blood glucose and insulin resistance control, and moderate intensity aerobic exercise was effective in reducing the cardiovascular risk index by increasing HDL-C levels.

참고문헌 (Reference)

1 이규성, "탄력밴드운동시 NIDDM 환자의 혈장내 Leptin 수준과 Insulin, Glucose 신체구성성분과의 관련성 분석" 한국운동생리학회 11 (11): 131-143, 2002

2 방윤이, "제 2형 당뇨병 여성 노인 환자의 혈당조절을 위한 국내 운동 프로그램의 효과분석" 한국산학기술학회 20 (20): 121-128, 2019

3 최철수, "인슐린저항성의 발생기전" 대한내과학회 77 (77): 171-177, 2009

4 곽효범, "골격근 미토콘드리아와 인슐린저항성: 운동의 역할" 대한비만학회 24 (24): 78-86, 2015

5 R. Taylor, "Type 2 diabetes: etiology and reversibility" 36 (36): 1047-1055, 2013

6 Lemieux, "Total cholesterol/HDL cholesterol ratio vs LDL cholesterol/HDL cholesterol ratio as indices of ischemic heart disease risk in men: the Quebec Cardiovascular Study" 161 (161): 2685-2692, 2001

7 A. H. Chen, "The role of triglyceride in cardiovascular disease in asian patients with type 2 diabetes—a systematic review" 10 (10): 101-109, 2013

8 E. Cauza, "The relative benefits of endurance and strength training on the metabolic factors and muscle function of people with type 2diabetes mellitus" 86 (86): 1527-1533, 2005

9 J. P. Kirwan, "The essential role of exercise in the management of type 2 diabetes" 84 (84): S15-S21, 2017

10 김지연, "The Preventive Effects of 8 Weeks of Resistance Training on Glucose Tolerance and Muscle Fiber Type Composition in Zucker Rats" 대한당뇨병학회 39 (39): 424-433, 2015

11 M. K. Holten, "Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes" 53 (53): 294-305, 2004

12 R. L. Seip, "Skeletal muscle lipoprotein lipase: molecular regulation and physiological effects in relation to exercise" 26 : 191-218, 1998

13 R. A. DeFronzo, "Skeletal muscle insulin resistance is the primary defect in type 2 diabetes" 32 : S157-S163, 2009

14 V. N. Cunha, "Role of exercise intensity on GLUT4 content, aerobic fitness and fasting plasma glucose in type 2 diabetic mice" 33 (33): 435-442, 2015

15 S. Bweir, "Resistance exercise training lowers HbA1c more than aerobic training in adults with type 2 diabetes" 1 (1): 27-, 2009

16 T. H. Ko, "Resistance exercise improves cardiac function and mitochondrial efficiency in diabetic rat hearts" 470 (470): 263-275, 2018

17 Y. Liu, "Resistance Exercise Intensity is Correlated with Attenuation of HbA1c and Insulin in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis" 16 (16): 140-, 2019

18 E. Teixeira-Lemos, "Regular physical exercise training assists in preventing type 2 diabetes development: focus on its antioxidant and anti-inflammatory properties" 10 (10): 12-, 2011

19 L. Florez, "Predictors of glycemic control after decline of insulin therapy by patients with type 2 diabetes" 107418-, 2019

20 S. Balducci, "Physical exercise as therapy for type 2 diabetes mellitus" 30 : 13-23, 2014

21 V. Schefer, "Oxygen consumption in adult and AGED C57BL/6J mice during acute treadmill exercise of different intensity" 31 (31): 387-392, 1996

22 F. S. Lira, "Low and moderate, rather than high intensity strength exercise induces benefit regarding plasma lipid profile" 2 : 31-, 2010

23 R. K. Avramoglu, "Lipid and lipoprotein dysregulation in insulin resistant states" 1 (1): 1-19, 2006

24 Klaus G. Parhofer, "Interaction between Glucose and Lipid Metabolism: More than Diabetic Dyslipidemia" 대한당뇨병학회 39 (39): 353-362, 2015

25 G. D. Cartee, "Influence of age on skeletal muscle glucose transport and glycogen metabolism" 26 (26): 577-585, 1994

26 H. Ishiguro, "In search of the ideal resistance training program to improve glycemic control and its indication for patients with type 2diabetes mellitus: a systematic review and meta-analysis" 46 (46): 67-77, 2016

27 N. H. Cho, "IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045" 138 : 271-281, 2018

28 B. Pan, "Exercise training modalities in patients with type 2 diabetes mellitus: a systematic review and network meta-analysis" 15 (15): 72-, 2018

29 E. T. de Lemos, "Exercise training decreases proinflammatory profile in Zucker diabetic(type 2)fatty rats" 25 (25): 330-339, 2009

30 S. R. Colberg, "Exercise and type 2 diabetes:the American College of Sports Medicine and the American Diabetes Association:joint position statement executive summary" 33 (33): 2692-2696, 2010

31 K. I. Stanford, "Exercise and type 2 diabetes : molecular mechanisms regulating glucose uptake in skeletal muscle" 38 (38): 308-314, 2014

32 W. T. Friedewald, "Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge" 18 (18): 499-502, 1972

33 W. E. Kraus, "Effects of the amount and intensity of exercise on plasma lipoproteins" 347 (347): 1483-1492, 2002

34 V. Chavanelle, "Effects of high-intensity interval training and moderate-intensity continuous training on glycaemic control and skeletal muscle mitochondrial function in db/db mice" 7 (7): 204-204, 2017

35 C. Nery, "Effectiveness of resistance exercise compared to aerobic exercise without insulin therapy in patients with type 2diabetes mellitus: a meta-analysis" 21 (21): 400-415, 2017

36 S. Balducci, "Effect of high- versus low-intensity supervised aerobic and resistance training on modifiable cardiovascular risk factors in type 2diabetes; the Italian Diabetes and Exercise Study (IDES)" 7 (7): e49297-, 2012

37 A. D. Mooradian, "Dyslipidemia in type 2diabetes mellitus" 5 (5): 150-159, 2009

38 L. Wu, "Diabetic dyslipidemia" 63 (63): 1469-1479, 2014

39 R. L. Marcus, "Comparison of combined aerobic and high-force eccentric resistance exercise with aerobic exercise only for people with type 2 diabetes mellitus" 88 (88): 1345-1354, 2008

40 M. Guerin, "Atherogenic role of elevated CE transfer from HDL to VLDL(1) and dense LDL in type 2 diabetes : impact of the degree of triglyceridemia" 21 (21): 282-288, 2001

41 D. B. Sacks, "A1C versus glucose testing : a comparison" 34 (34): 518-523, 2011

42 American Diabetes Association, "2. Classification and diagnosis of diabetes:standards of medical care in diabetes—2018" 41 : S13-S27, 2018